| George J. Karb | |
| Office1: | 30th and 39th Mayor of Columbus |
| Term Start1: | January 1, 1912 |
| Term End1: | January 1, 1920 |
| Predecessor1: | George S. Marshall |
| Successor1: | James J. Thomas |
| Term Start2: | 1891 |
| Term End2: | 1894 |
| Predecessor2: | Philip H. Bruck |
| Successor2: | Cotton H. Allen |
| Party: | Democratic |
| Profession: | Druggist County Sheriff Mayor Police Commissioner Member of City Council |
| Birth Name: | George John Karb |
| Birth Date: | 15 February 1858 |
| Birth Place: | Columbus, Ohio |
| Death Place: | Columbus, Ohio |
| Restingplace: | Green Lawn Abbey Columbus, Ohio |
| Residence: | 1788 Bryden Road Columbus, Ohio |
| Spouse: | Kate M. Van Dine |
George John Karb (February 15, 1858 – May 15, 1937) was the 30th and 39th mayor of Columbus, Ohio and the 27th person to serve in that office. He was first elected in 1890 and served Columbus for two consecutive terms. After four years as mayor, he was elected as Sheriff of Franklin County. He later resought election in the 1911 mayoral campaign and defeated incumbent Republican mayor George S. Marshall. He served Columbus as mayor during World War I and the Spanish Influenza of 1918. After three consecutive terms in office Karb was defeated in the 1919 mayoral election by James J. Thomas. Karb died on May 15, 1937.[1]