| George II | |
| Succession: | Landgrave of Hesse-Darmstadt |
| Reign: | 27 July 1626 – 11 June 1661 |
| Predecessor: | Louis V |
| Successor: | Louis VI |
| Issue: | Louis VI, Landgrave of Hesse-Darmstadt Elisabeth Amalie Anna Sophia II, Princess-Abbess of Quedlinburg |
| House: | Hesse-Darmstadt |
| Father: | Louis V, Landgrave of Hesse-Darmstadt |
| Mother: | Magdalene of Brandenburg |
| Birth Date: | 17 March 1605 |
| Birth Place: | Darmstadt |
| Death Date: | 11 June 1661 (aged 56) |
| Death Place: | Darmstadt |
George II of Hesse-Darmstadt, German: Georg II von Hessen-Darmstadt (17 March 1605, in Darmstadt – 11 June 1661) was the Landgrave of Hesse-Darmstadt from 1626 to 1661. He was the son of Ludwig V and Magdalene of Brandenburg.
He married Sophia Eleonore of Saxony on 1 April 1627. From 1645 to 1648 he led the so-called Hessenkrieg against the Landgravine Amalie Elizabeth of Hesse-Kassel over the inheritance of the extinct line of Hesse-Marburg. This conflict resulted in the loss of Hesse-Marburg to Hesse-Kassel.
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