George Chaldakov Explained

George Chaldakov
Birth Name:	George Nikov Chaldakov
Birth Date:	1940 2, df=yes
Birth Place:	Burgas, Bulgaria
Citizenship:	Bulgaria
Nationality:	Bulgarian
Fields:	Vascular Biology Adipobiology Neurobiology
Workplaces:	Medical University of Varna
Alma Mater:	Medical University of Varna (M.D.)(Ph.D.)
Known For:	Homo obesus
Awards:	Iuliu Hațieganu University of Medicine and Pharmacy (Doctor Honoris Causa)

George Nikov Chaldakov (Bulgarian: Георги Ников Чалдъков) born February 23, 1940, in Burgas, Bulgaria, is a Bulgarian vascular biologist well known for his contributions to the study of secretory function of vascular smooth muscle cells, and the role of neurotrophins and perivascular adipose tissue in pathogenesis of atherosclerosis.^[1] He published the first Bulgarian textbook of Cell Biology in 1996 and in 2005 founded the Bulgarian Society for Cell Biology.

In 1966 Chaldakov graduated as an MD from Varna Institute of Medicine (since 1991, named Medical University of Varna), Varna, Bulgaria.^[1] In 1983 he obtained a PhD in Vascular Biology, "Ultrastructural and cytopharmacological study of aging in vascular smooth muscle cells, with special reference to their secretory function".^[2] Since 2007, Chaldakov has served as Professor Emeritus at Medical University of Varna, Bulgaria.

For the past 30 years Chaldakov has been involved in interdisciplinary research in the fields of vascular biology, and has had relationship with suchadipobiology, and neurobiology and is one of the pioneers establishing the novel concept of the secretory function/phenotype of the vascular smooth muscle cells and further delineating their role in atherogenesis. Chaldakov developed a complex tripartite model of atherogenesis which involve smooth muscle cells, immune cells, and perivascular adipose tissue communicating through secreted factors (e.g. neurotrophins, adipokines, cytokines).

In 1991, Chaldakov became founder and chief editor of Biomedical Reviews, An International Journal of Cell Biology of Disease. He has also been an organizer of Biomedical Forum, Annual Program of Continuing Medical Education held at Medical University of Varna, Bulgaria.

Innovations and substantial contributions to science

• Concept of the secretory function/phenotype of the vascular smooth muscle cell, as related to atherogenesis.^{[3] [4] [5]}
• Tubulin/microtubule-targeted pharmacology for atherosclerosis.^{[6] [7] [8]}
• Concept of the neurotrophins NGF and BDNF as metabotrophic factors (metabotrophins) in cardiometabolic biology/diseases.^{[9] [10]}
• Conceptualize the protein secretory products of adipose tissue cells as adipokines, also focusing on perivascular adipose tissue.^{[11] [12] [13]}
• Conceptualize studying adipose tissue-directed pharmacology as adipopharmacology.^{[14] [15] [16]}
• In 2006 introduced the term Homo obesus and is actively involved in popularizing the need of healthy lifestyle and dietary restriction: millions of people suffer and die from starvation in ill-developed and poor countries while in Western world and Europe people get overweight and die as a result of strokes or heart infarctions.^{[17] [18]}

External links

• Bulgarian Society for Cell Biology
• Biomedical Reviews,
• Adipobiology,
• eMedicine - Atherosclerosis: Article by F Brian Boudi, MD
• The European Atherosclerosis Society
• Medical University of Varna Website

Notes and References

1. Web site: Biography of George Chaldakov . Bulgarian Society for Cell Biology . 25 February 2012 .
2. Web site: George N. Chaldakov . https://archive.today/20130801012852/http://endx.zglckf.com/Html/2009_08_12/2025_21510_2009_08_12_61517.html . dead . 1 August 2013 . Neural Regeneration Research . 25 February 2012 .
3. Book: Chaldakov GN, Nikolov SD . Ultrastructure of the arterial smooth muscle cell . Smooth Muscle of the Artery . Stewart Wolf . Nicholas Theodore Werthessen . Plenum Press . . 14–20 . 1975 . 978-0-306-39057-9 . 1288413.
4. Chaldakov GN, Nikolov SD, Vankov VN . Fine morphological aspects of the secretory process of arterial smooth muscle cells. II. Role of microtubules . Acta Morphologica Academiae Scientiarum Hungaricae . 25 . 167–174 . 1977 . 615419 . 2–3.
5. Chaldakov GN, Vankov VN . Morphological aspects of secretion in the arterial smooth muscle cell, with special reference to the Golgi complex and microtubular cytoskeleton . Atherosclerosis . 61 . 175–192 . 1986 . 10.1016/0021-9150(86)90137-1 . 3533092 . 3.
6. Chaldakov GN . Antitubulins - a new therapeutic approach for atherosclerosis? . Atherosclerosis . 44 . 385–390 . 1982 . 10.1016/0021-9150(82)90013-2 . 3.
7. Book: Chaldakov GN, Vankov VN . Antifibrotic approach in the therapy of arterial occlusive diseases: new considerations . Konservative Therapie arterieller Durchblutungsstörungen . Conservative Therapy of Arterial Occlusive Disease . Gustav Trübestein . . . 224–226 . 1986 . 978-3-13-688101-9 . 246829648.
8. Chaldakov GN . Anti-inflammatory drugs and ischemic heart disease: new considerations (a cell biologist's proposal to cardiologists) . Journal of the American College of Cardiology . 17 . 1445–1446 . 1991 . 2016465 . 6 . 10.1016/S0735-1097(10)80161-5. free .
9. Chaldakov GN, Fiore M, Hristova M, Aloe L . Metabotrophic potential of neurotrophins: implication in obesity and related diseases? . Medical Science Monitor . 9 . 10 . HY19–21 . 2003 . 14523335 .
10. Manni L, Nikolova V, Vyagova D, Chaldakov GN, Aloe L . Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes . International Journal of Cardiology . 102 . 169–171 . 2005 . 10.1016/j.ijcard.2004.10.041 . 15939120 . 1.
11. Chaldakov GN . Fiore M . Ghenev PI . Stankulov IS Aloe L . Atherosclerotic lesions: possible interactive involvement of intima, adventitia and associated adipose tissue . The International Medical Journal . 7 . 43–49 . 2000.
12. Chaldakov GN, Stankulov IS, Aloe L . Subepicardial adipose tissue in human coronary atherosclerosis: another neglected phenomenon . Atherosclerosis . 154 . 237–238 . 2001 . 10.1016/S0021-9150(00)00676-6 . 11190652 . 1.
13. Chaldakov GN, Stankulov IS, Fiore M, Ghenev PI, Aloe L . Nerve growth factor levels and mast cell distribution in human coronary atherosclerosis . Atherosclerosis . 159 . 57–66 . 2001 . 10.1016/S0021-9150(01)00488-9 . 11689207 . 1.
14. Chaldakov GN, Stankulov IS, Hristova MG, Ghenev PI . Adipobiology of disease: adipokines and adipokine-targeted pharmacology . Current Pharmaceutical Design . 9 . 1023–1031 . 2003 . 10.2174/1381612033455152 . 12678860 . 12.
15. Chaldakov GN, Fiore M, Hristova M, Aloe L . Cell biology and pharmacology of adipose tissue secretion . FABAD Journal of Pharmaceutical Sciences . 25 . 181–191 . 2000.
16. Chaldakov GN, Fiore M, Tonchev AB, Aloe L . Adipopharmacology, a novel drug discovery approach: a metabotrophic perspective . Letters in Drug Design & Discovery . 3 . 503–505 . 2006 . 10.2174/157018006778194835 . 7.
17. Chaldakov GN, Fiore M, Tonchev AB, Dimitrov D, Pancheva R, Rancic G, Aloe L . Homo obesus: a metabotrophin-deficient species. Pharmacology and nutrition insight . Current Pharmaceutical Design . 13 . 2176–2179 . 2007 . 10.2174/138161207781039616 . 17627549 . 21.
18. Web site: HOMO OBESUS? (cream of broccoli and cashew soup). Bethany Klug. 2008. The Doctor Cooks. 25 February 2012. https://web.archive.org/web/20110806174158/http://www.thedoctorcooks.com/2008/03/homo-obesus.html. 6 August 2011. dead.