| George Bruce Upton | |
| Birth Date: | October 11, 1804 |
| Death Date: | July 1, 1874 (aged 70) |
| Nationality: | American |
| Occupation: | Dry goods clerk, Shipbuilder |
| Children: | George Bruce Upton |
| Office: | Member of the Massachusetts Executive Council |
| Term: | 1853 |
| Office2: | Member of the Massachusetts Constitutional Convention of 1853 |
| Term2: | 1853 |
| Office3: | Member of the Massachusetts Senate Nantucket and Dukes County District |
| Term3: | 1843 |
| Predecessor3: | Barker Burnell |
| Successor3: | Obed Barney |
| Office4: | Member of the Massachusetts House of Representatives Nantucket District |
| Term4: | 1837 |
| Signature: | George_Bruce_Upton_signature.png |
George Bruce Upton (October 11, 1804 – July 1, 1874) was an American shipbuilder and politician who served in the Massachusetts House of Representatives, the Massachusetts Senate and the Massachusetts Executive Council.
Upton was born on October 11, 1804, to Daniel Putnam Upton and Hannah (Bruce) Upton in Eastport, Maine (then a part of Massachusetts).
Upton married Ann Coffin Hussey of Nantucket on May 2, 1826. They had eight children.
Upton served as the treasurer of the Michigan Central Railroad for eight years.
While he lived in Nantucket Upton was a member of the Massachusetts House of Representatives in 1837, and a member of the Massachusetts Senate in 1843. After he moved back to Boston Upton served as a member of the Massachusetts Executive Council in 1853, and as a member of the Massachusetts Constitutional Convention of 1853.
Upton served as delegate to the Whig National Convention in 1844.