Gentianine Explained

Gentianine is a pyridine-derived alkaloid. Originally isolated in 1944 from Gentiana kirilowi,^[1] it has also been found in Gentiana macrophylla,^[2] fenugreek,^[3] Strychnos angolensis,^[4] Strychnos xantha,^[4] and other plants.

Gentianine is a crystalline solid with a melting point of 82-83 °C. It is a base that forms salts, such as the hydrochloride salt, upon treatment with acids.

Gentianine has been studied for its potential anti-inflammatory properties.^{[2] [5] [6] [7]}

Notes and References

1. Proskurnina (1944), J. Gen. Chem. USSR, 14, 1148.
2. 10.1248/bpb.28.750 . Effects of Gentianine on the Production of Pro-inflammatory Cytokines in Male Sprague-Dawley Rats Treated with Lipopolysaccharide (LPS) . 2005 . Kwak . Wie-Jong . Kim . Joo-Hyon . Ryu . Keun-Ho . Cho . Yong-Baik . Jeon . Sun-Duck . Moon . Chang-Kiu . Biological and Pharmaceutical Bulletin . 28 . 4 . 750–753 . 15802824 . free .
3. Web site: Gentianine (FDB007359) . FooDB . The Metabolomics Innovation Centre . June 30, 2022 .
4. Web site: Gentianine . . June 30, 2022 .
5. 10.1007/s10753-017-0583-8 . Protective Effect of Gentianine, a compound from du Huo Ji Sheng Tang, against Freund's Complete Adjuvant-Induced Arthritis in Rats . 2017 . Wenjin . Chen . Jianwei . Wang . Inflammation . 40 . 4 . 1401–1408 . 28501981 . 4476482 .
6. 10.1016/j.phrs.2021.105913 . Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury . 2021 . Wang . Na . Liu . Yao . Jia . Caixia . Gao . Chengwen . Zheng . Ting . Wu . Mingxuan . Zhang . Qian . Zhao . Xiangzhong . Li . Zhiqiang . Chen . Jianxin . Wu . Chuanhong . Pharmacological Research . 173 . 105913 . 34563661 . 237942721 .
7. 10.1016/j.jtcme.2016.12.013 . Medicinal, biological and phytochemical properties of Gentiana species . 2017 . Mirzaee . Fatemeh . Hosseini . Amirsaeed . Jouybari . Hossein Bakhshi . Davoodi . Ali . Azadbakht . Mohammad . Journal of Traditional and Complementary Medicine . 7 . 4 . 400–408 . 29034186 . 5634738 .