Gentamicin 3'-N-acetyltransferase explained

gentamicin 3'-N-acetyltransferase
Ec Number:	2.3.1.60
Cas Number:	58500-58-6
Go Code:	0016991

In enzymology, a gentamicin 3'-N-acetyltransferase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + gentamicin C

\rightleftharpoons CoA + N₃'-acetylgentamicin C

Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C, whereas its two products are CoA and N3'-acetylgentamicin C.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C N3'-acetyltransferase. Other names in common use include gentamicin acetyltransferase I, aminoglycoside acetyltransferase AAC(3)-1, gentamicin 3'-N-acetyltransferase, and acetyl-CoA:gentamicin-C N3'-acetyltransferase.

References

• Angelatou F, Litsas SB, Kontomichalou P . Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa . J. Antibiot. . 235 - 44 . 6281224 . 2 . 35 . February 1982 . 10.7164/antibiotics.35.235. free .
• Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ . 1976 . Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate . Antimicrob. Agents Chemother. . 9 . 951 - 5 . 820250 . 6 . 429656 . 10.1128/aac.9.6.951.
• Williams JW, Northrop DB . 1976 . Purification and properties of gentamicin acetyltransferase I . Biochemistry . 15 . 125 - 31 . 764855 . 10.1021/bi00646a019 . 1 .