Gentamicin 2"-nucleotidyltransferase explained
| gentamicin 2"-nucleotidyltransferase |
| Ec Number: | 2.7.7.46 |
| Cas Number: | 62213-33-6 |
| Go Code: | 0008871 |
In enzymology, a gentamicin 2"-nucleotidyltransferase is an enzyme that catalyzes the chemical reaction
nucleoside triphosphate + gentamicin
diphosphate + 2"-nucleotidylgentamicin
Thus, the two substrates of this enzyme are nucleoside triphosphate and gentamicin, whereas its two products are diphosphate and 2-nucleotidylgentamicin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:gentamicin 2"-nucleotidyltransferase. Other names in common use include gentamicin 2"-adenylyltransferase, aminoglycoside adenylyltransferase, and gentamicin 2"-nucleotidyltransferase.
References
- Angelatou F, Litsas SB, Kontomichalou P . Tokyo . Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa . J. Antibiot. . 235 - 44 . 6281224 . 2 . 35. February 1982 . 10.7164/antibiotics.35.235. free .
- Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H . Tokyo . The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B . J. Antibiot. . 913 - 4 . 4946513 . 12 . 24 . December 1971 . 10.7164/antibiotics.24.913. free .
- Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T . Tokyo . Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor . J. Antibiot. . 911 - 2 . 4946512 . 12 . 24. December 1971 . 10.7164/antibiotics.24.911. free .
