Genous Explained

Genous is an endothelial progenitor cell (EPC) capture technology manufactured by OrbusNeich that promotes the accelerated natural healing of the vessel wall after stent implantation. The pro-healing technology has an antibody surface coating that captures circulating CD34+ endothelial progenitor cells to the device, forming a functional endothelial layer over the stent to protect against thrombus and minimize restenosis.^{[1] [2]}

The Genous Stent is a bio-engineered coronary stent coated with immobilized anti-CD34 monoclonal antibodies specific to the Genous technology.^{[3] [4]}

The Combo Dual Therapy Stent is a coronary stent that combines Genous with an antiproliferative, biodegradable sirolimus drug elution. The Combo Stent was shown to be as effective as a paclitaxel-eluting stent in controlling Neointimal Hyperplasia.^{[5] [6] [7]}

External links

• OrbusNeich Web site

Notes and References

1. Bylander, Jessica (27 October 2008). "New Stents On The Block: Innovators Look Beyond Drug Coatings." The Gray Sheet.
2. http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/%7Bc4490368-d6db-457e-b9b2-ce6786b1ebc4%7D/novel-stent-promotes-healing-of-vessel-wall-after-implantation "Novel stent promotes healing of vessel wall after implantation"
3. Klomp M, Beijk MA, de Winter RJ . July 2009 . Genous™ endothelial progenitor cell-capturing stent system: a novel stent technology . Expert Review of Medical Devices . 6 . 4 . 365–375 . 28 August 2012 . 10.1586/erd.09.16. 19572791 . 22534986 .
4. http://www.cxvascular.com/cn-latest-news/cardiovascular-news---latest-news/genous-stent-is-a-safe-and-effective-option-in-stemi-patients- "Genous stent is a safe and effective option in STEMI patients"
5. London, Susan (14 November 2011). "Bioengineered, Sirolimus-Eluting Stent Found ‘Safe,’ and ‘Effective.’" Cardiology News.
6. http://www.healio.com/cardiology/intervention/news/print/cardiology-today-intervention/%7Bd6561e10-c5c0-4c9d-afbd-f65922406b27%7D/dual-therapy-stenting-the-next-step-in-the-evolution-of-stent-design- "Dual-Therapy Stenting: The Next Step in the Evolution of Stent Design"
7. http://www.medpagetoday.com/MeetingCoverage/TCT/29632 "TCT: Combo Stent Comparable to Taxus"