| General Obligado Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of General Obligado in Argentina |
| Coordinates: | -29.6667°N -71°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Santa Fe |
| Seat Type: | Head town |
| Seat: | Reconquista |
| Unit Pref: | Metric |
| Area Total Km2: | 10928 |
| Population Total: | 166436 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
The General Obligado Department (in Spanish, Departamento General Obligado) is an administrative subdivision (departamento) of the province of Santa Fe, Argentina. It is located in the northeast of the province. It has about 166,000 inhabitants as per the . Its head town is the city of Reconquista (population 66,000).
The department is located on the northeastern "corner" of Santa Fe, bordered by the Vera Department in the west and the San Javier Department in the south. In the north it limits with the province of Chaco, and in the east, with the Paraná River, which is the natural border with the province of Corrientes.
The towns and cities in this department are (in alphabetical order): Arroyo Ceibal, Avellaneda, Berna, El Arazá, El Rabón, El Sombrerito, Florencia, Guadalupe Norte, Ingeniero Chanourdie, Hardy, La Sarita, Lanteri, Las Garzas, Las Toscas, Los Laureles, Malabrigo, Nicanor E. Molinas, Reconquista, San Antonio de Obligado, Tacuarendí, Villa Ana, Villa Guillermina, Villa Ocampo.