| General Güemes Department | |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | 180px |
| Pushpin Map Caption: | Location of General Güemes Department in Argentina |
| Coordinates: | -25.9333°N -97°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco Province |
| Seat Type: | Head town |
| Seat: | Juan José Castelli |
| Unit Pref: | Metric |
| Area Total Km2: | 25,487 |
| Population Total: | 62,227 |
| Population Density Km2: | auto |
| Population Demonym: | Güemesense |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code: | H3705 |
| Area Code: | 03732 |
General Güemes is the largest and the northernmost department of Chaco Province in Argentina.
The provincial subdivision has a population of about 62,000 inhabitants in an area of 25,487 km2, and its capital city is Juan José Castelli, which is located around 1,305 km from the Capital federal.