| General Güemes | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of General Güemes in Argentina |
| Coordinates: | -24.6667°N -68°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | General Güemes |
| Unit Pref: | Metric |
| Elevation M: | 295 |
| Population Total: | 47348 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | A4430 |
| Area Code Type: | Dialing code |
| Area Code: | +54 387 |
| Blank Name: | Climate |
| Blank Info: | BSh |
General Güemes, sometimes shortened in Güemes, is a town in the center of the province of Salta, Argentina. It has 47,348 inhabitants as per the, and is the head town of the General Güemes Department.
It lies about 45 km east-northeast from the provincial capital Salta, on National Route 9. Its name is an homage to caudillo Martín Miguel de Güemes (1785–1821), hero of the Argentine War of Independence.
In 2008, the city gained media attention after sightings of a "mysterious gnome" were reported.
General Güemes is the terminus station of narrow gauge train that connects it to Salta.