Gene-activated matrix explained

In gene-activated matrix technology (GAM), cytokines and growth factors could be delivered not as recombinant proteins but as plasmid genes.^[1] GAM is one of the tissue engineering approaches to wound healing. Following gene delivery, the recombinant cytokine could be expressed in situ by endogenous would healing cells – in small amounts but for a prolonged period of time – leading to reproducible tissue regeneration. The matrix can be modified by incorporating a viral vector, mRNA or DNA bound to a delivery system, or a naked plasmid.^[2]

External links

Cardium Presents Gene Activated Matrix Technology And Update On Excellarate Clinical Development Program At ASGT Annual Meeting

Notes and References

Review: Local Gene Delivery for Tissue Regeneration. Jeffrey. Bonadio. E-biomed: The Journal of Regenerative Medicine. 1. 2. 25–29. 2000. 10.1089/152489000414552.
Krasilnikova . O. . Yakimova . A. . Ivanov . S. . Atiakshin . D. . Kostin . A.A. . Sosin . D. . Shegay . P. . Kaprin . A.D. . Klabukov . I. . 2023 . Gene-Activated Materials in Regenerative Dentistry: Narrative Review of Technology and Study Results . International Journal of Molecular Sciences . 24 . 22 . 16250 . 10.3390/ijms242216250 . 1422-0067 . 10671237 . 38003439 . free .