Gemeprost Explained

Gemeprost (16, 16-dimethyl-trans-delta2 PGE₁ methyl ester) is an analogue of prostaglandin E₁.

Clinical use

It is used as a treatment for obstetric bleeding.

It is used with mifepristone to terminate pregnancy up to 24 weeks gestation.^[1]

Side effects

Vaginal bleeding, cramps, nausea, vomiting,^[2] loose stools or diarrhea,^[2] headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild pyrexia.^[2] Rare: Uterine rupture, severe hypotension, coronary spasms with subsequent myocardial infarctions.

External links

• Web site: Gemeprost . U.S. National Library of Medicine . Drug Information Portal .

Notes and References

1. Bartley J, Brown A, Elton R, Baird DT . Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or misoprostol for induction of abortion up to 63 days gestation . Human Reproduction . 16 . 10 . 2098–102 . October 2001 . 11574498 . 10.1093/humrep/16.10.2098 . free .
2. Book: Aronson, J. K. . Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions . Elsevier Science . 2015 . 978-0-4445-3716-4 . 524.