Gem-associated protein 6 explained

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.^{[1] [2]} The gem-associated proteins are those found in the gems of Cajal bodies.

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.^{[3] [4]}

Further reading

• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G . Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex . The Journal of Biological Chemistry . 277 . 35 . 31957–62 . Aug 2002 . 12065586 . 10.1074/jbc.M203478200 . free .
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD . The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure . Structure . 13 . 6 . 883–92 . Jun 2005 . 15939020 . 10.1016/j.str.2005.03.014 . free .
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L . Gemin8 is required for the architecture and function of the survival motor neuron complex . The Journal of Biological Chemistry . 281 . 48 . 37009–16 . Dec 2006 . 17023415 . 10.1074/jbc.M607505200 . free .

Notes and References

1. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G . Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component . The Journal of Biological Chemistry . 277 . 9 . 7540–5 . Mar 2002 . 11748230 . 10.1074/jbc.M110141200 . free .
2. Web site: Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6.
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G . Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex . The Journal of Biological Chemistry . 277 . 35 . 31957–62 . Aug 2002 . 12065586 . 10.1074/jbc.M203478200 . free .