Geiparvarin Explained

Geiparvarin is a coumarin derivative found in the leaves of the Australian Willow (Geijera parviflora).^[1] It is a monoamine oxidase inhibitor.^[2]

Several analogues of geiparvarin have been studied for antitumor properties.^{[3] [4] [5]}

Notes and References

1. Lahey FN, Macleod JK . The coumarins of Geijera parviflora Lindl . . 20 . 9 . 1943–55 . September 1967 . 10.1071/CH9671943.
2. Carotti A . Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies . Bioorg. Med. Chem. Lett. . 12 . 24 . 3551–3555 . December 2002 . 12443774 . 10.1016/S0960-894X(02)00798-9. vanc. Carrieri A . Chimichi S . 3 . Boccalini . M . Cosimelli . B . Gnerre . C . Carotti . A . Carrupt . PA . Testa . B.
3. Baraldi PG, Guarneri M, Manfredini S, Simoni D, Balzarini J, De Clercq E . Synthesis and cytostatic activity of geiparvarin analogues . . 32 . 2 . 284–288 . February 1989 . 2913291 . 10.1021/jm00122a002.
4. Valenti P . Synthesis, cytotoxicity and SAR of simple geiparvarin analogues . Anticancer Drug Des . 12 . 6 . 443–51 . September 1997 . 9311554 . vanc. Rampa A . Recanatini M . 3 . Bisi . A . Belluti . F . Da Re . P . Carrara . M . Cima . L.
5. Viola G . Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues . Chemistry & Biodiversity . 1 . 9 . 1265–1280 . September 2004 . 17191904 . 10.1002/cbdv.200490089 . vanc. Vedaldi D . dall'Acqua F . 3 . Basso . Giuseppe . Disarò . Silvia . Spinelli . Monica . Cosimelli . Barbara . Boccalini . Marco . Chimichi . Stefano. 22355393 .