Gastrokine-1 Explained

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.^{[1] [2] [3]}

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.^[3]

Further reading

• Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I . Isolation of two novel genes, down-regulated in gastric cancer . Japanese Journal of Cancer Research . 91 . 5 . 459–63 . May 2000 . 10835488 . 5926377 . 10.1111/j.1349-7006.2000.tb00967.x .
• Westley BR, Griffin SM, May FE . Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C . Biochemistry . 44 . 22 . 7967–75 . June 2005 . 15924415 . 10.1021/bi047287n .
• Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG . AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins . American Journal of Physiology. Gastrointestinal and Liver Physiology . 289 . 1 . G163-71 . July 2005 . 15961882 . 1444946 . 10.1152/ajpgi.00013.2005 .
• Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, Cacace G, Malorni A, Budillon G, Arcari P . 6 . Gastrokine 1 expression in patients with and without Helicobacter pylori infection . Digestive and Liver Disease . 39 . 2 . 122–9 . February 2007 . 17092786 . 10.1016/j.dld.2006.09.017 .

Notes and References

1. Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG . A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa . American Journal of Physiology. Gastrointestinal and Liver Physiology . 285 . 2 . G332-43 . August 2003 . 12851218 . 10.1152/ajpgi.00453.2002 . 2860022 . https://web.archive.org/web/20190302130618/http://pdfs.semanticscholar.org/9c7e/d2ad52d32efc8e92507716d7c827be6766fb.pdf . dead . 2019-03-02 .
2. Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, Dono K, Umeshita K, Sakon M, Furukawa H, Hiratsuka M, Kasugai T, Ishiguro S, Monden M . 6 . Human stomach-specific gene, CA11, is down-regulated in gastric cancer . International Journal of Oncology . 19 . 4 . 701–7 . October 2001 . 11562744 . 10.3892/ijo.19.4.701 .
3. Web site: Entrez Gene: GKN1 gastrokine 1.