Gary Desir Explained

Gary Desir
Birth Name:Gary V. Desir
Alma Mater:New York University
Yale University
Known For:Discovery of Renalase
Field:Nephrology and molecular physiology
Work Institutions:Yale University
Yale School of Medicine
VA Connecticut Healthcare System
School of Forestry and Environmental Studies
Albert Schweitzer Hospital
Spouses:Deborah Dyett Desir[1] [2]

Gary V. Desir is a physician, researcher and medical practitioner who was appointed as the vice provost for faculty development and diversity at Yale University in March 2020.[3] [4] [5] Desir is also the chair of the department of internal medicine at Yale School of Medicine, and was formerly the chair of the Yale Medicine Board. His areas of specialization include nephrology and molecular physiology, the latter specifically about potassium channels.[6] His notable research work includes discovery of the kidney protein renalase.[7] [8] [9]

Early life and career

Desir was born in Haiti[10] and has studied rhétorique from St Louis de Gonzague. He moved to the US in 1972 and in 1973 he enrolled in the bachelors program at New York University. In 1976, he graduated as a BS in biology while receiving the membership of Phi Beta Kappa.[11] In 1980, he graduated with honors from Yale University and became part of the Alpha Omega Alpha.[12] From 1980 to 1983 he trained in internal medicine. He took part in the fellowship program in nephrology. He worked for 3 years as the research fellowship at Yale University in nephrology with specialization in potassium channels (molecular physiology).

In 1988, Desir was appointed as an assistant professor at Yale School of Medicine. He became associate professor and professor in 1993 and 2003 respectively. From 1997 to 2004, he served as the section chief of nephrology at the VA Connecticut Healthcare System. He worked as the chair of internal medicine at VACHS from 2004 to 2013.[13] In 2013, he was appointed on interim basis as the chair of the department of internal medicine at Yale School of Medicine.[14] He was appointed to the permanent chair in 2015.[15] In 2016 Desir was designated as the Paul B. Beeson Professor of Internal Medicine at Yale.[16] Desir is also vice provost for faculty development and diversity.[17] [18]

Research activities

Desir's most notable research activity include the discovery of the agent renalase, which is basically a renal protein. It can be classified as an enzyme as well as a hormone - such nature being decided on its site of action with the prospect of being used in dual-purpose.[19] The primary function of renalase is as an intracellular enzyme that controls and manipulates energy production at granular level. It also has the protective characteristics that it exhibits against cell injury and stress, once it secretes in the plasma.[20] [21]

Desir is also the founder of biotech firm Personal Therapeutics, that works exploring the prospects of commercializing renalase and its pathway while basing the foundations in two concepts, viz. renalase agonist and renalase antagonist. Renalase agonist primarily deals with the role of renalase in mitigating tissue injury in myocardial infarction whereas renalase antagonist is based on the concept of fighting cancer cells[22] which "highjack the renalase pathway as a survival mechanism".[23] [24] [25] During covid-19 pandemic, a correlation was claimed in a Yale researchers report between low levels of the renalase and poor outcome of clinical treatment of covid patients.[26] [27]

Other activities

Desir is an active advocate of diversity, equity and inclusion[28] and a founding member of the Minority Organization for Retention & Expansion executive committee of Yale.[29] [30] Under dual teaching appointment, Desir conducts the graduate course "Sustainable Development in a Post-Disaster Context" at the School of Forestry and Environmental Studies, in collaboration with the Albert Schweitzer Hospital in Deschapelles, Haiti.[31]

Notable publications

External links

Notes and References

  1. News: 1979-04-08. Deborah E. Dyett And Gary DeSir Set Bridal for Aug. 26. en-US. The New York Times. 2021-09-29. 0362-4331.
  2. Web site: Theta Epsilon Omega Chapter - Deborah Dyett Desir, MD, Joins ACR Executive Committee as Secretary. 2021-09-29. www.akanewhaven.org.
  3. Web site: Parry. Julie. Desir Named Vice Provost for Faculty Development and Diversity. 2021-09-17. medicine.yale.edu. en.
  4. Web site: 2020-10-14. Founders Day: Building a Stronger and More Inclusive Yale. 2021-09-17. Office of the President. en.
  5. Web site: Stevens. Chester. 2020-10-14. Salovey unveils new plans for equity, belonging at Yale. 2021-09-17. University News HQ. en-GB.
  6. Web site: amhe.org. 2021-09-17. en-US.
  7. Web site: 2020-06-07. Kidney enzyme renalase a potential therapy for severe COVID-19. 2021-09-17. News-Medical.net. en.
  8. Web site: 2020-07-01. What is Renalase?. 2021-09-17. News-Medical.net. en.
  9. Guo. Xiaojia. Hollander. Lindsay. MacPherson. Douglas. Wang. Ling. Velazquez. Heino. Chang. John. Safirstein. Robert. Cha. Charles. Gorelick. Fred. Desir. Gary V.. 2016-03-14. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Scientific Reports. en. 6. 1. 22996. 10.1038/srep22996. 26972355. 4789641. 2016NatSR...622996G . 2045-2322.
  10. Web site: Parry. Julie. Desir Shares Life Story, Advice in "The Importance of Being Present". 2021-09-17. medicine.yale.edu. en.
  11. Web site: Gary V. Desir, M.D., appointed Chair and Chief of Internal Medicine. 2021-09-17. medicine.yale.edu. en.
  12. Web site: Gary Desir, MD. 2021-09-17. medicine.yale.edu. en.
  13. Web site: Gary V. Desir, M.D., appointed Chair and Chief of Internal Medicine. 2021-09-17. medicine.yale.edu. en.
  14. Web site: Gary V. Desir, M.D., HS '83, FW '87, named interim chair of internal medicine. 2021-09-17. medicine.yale.edu. en.
  15. Web site: More news about Yale people. 2021-09-17. yalealumnimagazine.com. en.
  16. Web site: 2016-09-06. Dr. Gary Desir designated the Beeson Professor of Internal Medicine. 2021-09-17. YaleNews. en.
  17. Web site: DIM Comp R2. 2021-09-29. Issuu. en.
  18. Book: 2020. Sanger. Catherine Shea. Gleason. Nancy W.. Diversity and Inclusion in Global Higher Education. en-gb. 10.1007/978-981-15-1628-3. 978-981-15-1627-6 . 237868497 .
  19. Web site: Gary Desir. 2021-09-17. Yale Medicine. en.
  20. Desir. Gary. Novel insights into the physiology of renalase and its role in hypertension and heart disease. Pediatric Nephrology (Berlin, Germany). 2012. 27. 5. 719–725. 10.1007/s00467-011-1828-7. 1432-198X. 21424526. 8473507.
  21. Web site: Desir. Gary. Renalase Deficiency and Cardiovascular Complications of Chronic Kidney Disease. en.
  22. Web site: Grace. Castillo. 2016-03-29. Potential treatment for pancreatic cancer on horizon. 2021-09-17. Yale Daily News. en.
  23. Web site: AMHE Newsletter. In this number. Winter Haitian Medical Association Abroad Association Medicale Haïtienne à l'étranger. - PDF Free Download. 2021-09-17. docplayer.fr.
  24. Guo. Xiaojia. Hollander. Lindsay. MacPherson. Douglas. Wang. Ling. Velazquez. Heino. Chang. John. Safirstein. Robert. Cha. Charles. Gorelick. Fred. Desir. Gary V.. 2016-03-14. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Scientific Reports. en. 6. 1. 22996. 10.1038/srep22996. 26972355. 4789641. 2016NatSR...622996G . 2045-2322.
  25. Wang. Yang. Safirstein. Robert. Velazquez. Heino. Guo. Xiao-Jia. Hollander. Lindsay. Chang. John. Chen. Tian-Min. Mu. Jian-Jun. Desir. Gary V.. Extracellular renalase protects cells and organs by outside-in signalling. Journal of Cellular and Molecular Medicine. 2017. 21. 7. 1260–1265. 10.1111/jcmm.13062. 1582-1838. 5487909. 28238213.
  26. Web site: Blood protein predicts poor COVID-19 outcomes. 2021-09-17. medicalxpress.com. en.
  27. Web site: 2020-06-07. Kidney enzyme renalase a potential therapy for severe COVID-19. 2021-09-17. News-Medical.net. en.
  28. Web site: Parry. Julie. Diversity, Equity, Inclusion Focus Of Department of Internal Medicine. 2021-09-17. medicine.yale.edu. en.
  29. Web site: Who We Are. 2021-09-17. medicine.yale.edu. en.
  30. Web site: 2016-04-24. "Black Women in Medicine" Documentary to Screen at Yale on Tuesday 4/26. 2021-09-17. Good Black News. en-US.
  31. Web site: Amy. Xiong. 2018-03-30. Global Health Day addresses climate change. 2021-09-17. Yale Daily News. en.
  32. Xu. Jianchao. Li. Guoyong. Wang. Peili. Velazquez. Heino. Yao. Xiaoqiang. Li. Yanyan. Wu. Yanling. Peixoto. Aldo. Crowley. Susan. Desir. Gary V.. 2005-05-02. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Journal of Clinical Investigation. en. 115. 5. 1275–1280. 10.1172/JCI24066. 0021-9738. 1074681. 15841207.
  33. Gutman. George A.. Chandy. K. George. Adelman. John P.. Aiyar. Jayashree. Bayliss. Douglas A.. Clapham. David E.. Covarriubias. Manuel. Desir. Gary V.. Furuichi. Kiyoshi. Ganetzky. Barry. Garcia. Maria L.. 2003-12-01. International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels. Pharmacological Reviews. 55. 4. 583–586. 10.1124/pr.55.4.9. 14657415. 34963430.
  34. Hebert. Steven C.. Desir. Gary. Giebisch. Gerhard. Wang. Wenhui. 2005-01-01. Molecular Diversity and Regulation of Renal Potassium Channels. Physiological Reviews. 85. 1. 319–371. 10.1152/physrev.00051.2003. 0031-9333. 2838721. 15618483.
  35. Li. Guoyong. Xu. Jianchao. Wang. Peili. Velazquez. Heino. Li. Yanyan. Wu. Yanling. Desir. Gary V.. 2008-03-11. Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase. Circulation. 117. 10. 1277–1282. 10.1161/CIRCULATIONAHA.107.732032. 18299506. 6658935. free.
  36. Xu. Jianchao. Wang. Peili. Li. Yanyan. Li. Guoyong. Kaczmarek. Leonard K.. Wu. Yanling. Koni. Pandelakis A.. Flavell. Richard A.. Desir. Gary V.. 2004-03-02. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings of the National Academy of Sciences. 101. 9. 3112–3117. 10.1073/pnas.0308450100. 365752. 14981264. 2004PNAS..101.3112X . free.
  37. Xu. J.. 2003-03-01. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics. 12. 5. 551–559. 10.1093/hmg/ddg049. 12588802. 1460-2083. free.
  38. Kunchaparty. Shanti. Palcso. Matthew. Berkman. Jennifer. Velázquez. Heino. Desir. Gary V.. Bernstein. Paul. Reilly. Robert F.. Ellison. David H.. 1999-10-01. Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome. American Journal of Physiology. Renal Physiology. 277. 4. F643–F649. 10.1152/ajprenal.1999.277.4.F643. 10516289. 1931-857X.
  39. Desir. Gary V.. Regulation of blood pressure and cardiovascular function by renalase. Kidney International. 2009. 76. 4. 366–370. 10.1038/ki.2009.169. 19471322. 0085-2538. free.
  40. Desir. Gary V.. Tang. LieQi. Wang. Peili. Li. Guoyong. Sampaio-Maia. Benedita. Quelhas-Santos. Janete. Pestana. Manuel. Velazquez. Heino. Renalase Lowers Ambulatory Blood Pressure by Metabolizing Circulating Adrenaline. Journal of the American Heart Association. 2012. 1. 4. e002634. 10.1161/JAHA.112.002634. 3487338. 23130169.
  41. Farzaneh-Far. Ramin. Desir. Gary V.. Na. Beeya. Schiller. Nelson B.. Whooley. Mary A.. 2010-10-20. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE. en. 5. 10. e13496. 10.1371/journal.pone.0013496. 1932-6203. 2958117. 20975995. 2010PLoSO...513496F . free.
  42. Desir. Gary V.. Peixoto. Aldo J.. 2013-10-17. Renalase in hypertension and kidney disease. Nephrology Dialysis Transplantation. 29. 1. 22–28. 10.1093/ndt/gft083. 24137013. 1460-2385. free.

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