| Garhi Khairo Taluka | |
| Native Name: | Urdu: {{nq|تعلقہ گڑھی خیرو Sindhi: {{script/Arabic|ڳڙهي خيرو تعلقو |
| Settlement Type: | Taluka (Tehsil) |
| Subdivision Type: | Country |
| Subdivision Name: |  Pakistan |
| Subdivision Type1: | Province |
| Subdivision Name2: | Larkana Division |
| Subdivision Type2: | Division |
| Subdivision Type3: | District |
| Subdivision Name3: | Jacobabad District |
| Postal Code: | 79050 |
| Postal Code Type: | Post Code |
| Population Total: | 159,019 |
Garhi Khairo (Sindhi: ڳڙهي خيرو) is a Town and Tehsil in Jacobabad District Sindh. According to 2017 Census population of Garhi Khairo is 159,019 Garhi Khairo is connected with Jacobabad, Shikarpur, Qambar, It also shares Sindh border with Balochistan from Usta Muhammad side.