Garetosmab Explained
| Drug Name: | Garetosmab |
| Synonyms: | REGN-2477 |
| Type: | mab |
| Target: | Activin A |
| Legal Status: | Investigational |
| Unii: | KR9ZSKO5QE |
| Cas Number: | 2097125-54-5 |
Garetosmab is a fully human, experimental monoclonal antibody against activin-A. It has been tried in patients with fibrodysplasia ossificans progressiva and the manufacturer, Regeneron, also plans to test it in patients with obesity as an add-on to existing weight loss drugs such as GLP-1 agonists, in order to help patients maintain muscle mass during weight loss.[1] [2] [3]
Notes and References
- News: In obesity, Regeneron wants to fill gaps. But for cell therapy? George Yancopoulos wants to try something new . fiercebiotech.com . 6 March 2024.
- Di Rocco . Maja . Forleo-Neto . Eduardo . Pignolo . Robert J. . Keen . Richard . Orcel . Philippe . Funck-Brentano . Thomas . Roux . Christian . Kolta . Sami . Madeo . Annalisa . Bubbear . Judith S. . Tabarkiewicz . Jacek . Szczepanek . Małgorzata . Bachiller-Corral . Javier . Cheung . Angela M. . Dahir . Kathryn M. . Botman . Esmée . Raijmakers . Pieter G. . Al Mukaddam . Mona . Tile . Lianne . Portal-Celhay . Cynthia . Sarkar . Neena . Hou . Peijie . Musser . Bret J. . Boyapati . Anita . Mohammadi . Kusha . Mellis . Scott J. . Rankin . Andrew J. . Economides . Aris N. . Trotter . Dinko Gonzalez . Herman . Gary A. . O’Meara . Sarah J. . DelGizzi . Richard . Weinreich . David M. . Yancopoulos . George D. . Eekhoff . E. Marelise W. . Kaplan . Frederick S. . Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial . Nature Medicine . October 2023 . 29 . 10 . 2615–2624 . 10.1038/s41591-023-02561-8. 37770652 . 10579054 .
- Wang . Yuhuan . Nguyen . Jenny-Hoa . de Ruiter . Ruben R D . Mendell . Jeanne . Srinivasan . Dushyanth . Davis . John D . Eekhoff . Marelise W . THU467 Pharmacokinetics And Pharmacodynamics Of Garetosmab In Patients With Fibrodysplasia Ossificans Progressiva . Journal of the Endocrine Society . 5 October 2023 . 7 . Supplement_1 . bvad114.428 . 10.1210/jendso/bvad114.428. free . 10554036 .
