Gandy–Gamna nodules explained

Gandy–Gamna nodules or Gandy-Gamna bodies, sometimes known as Gamna-Gandy bodies or Gamna-Gandy nodules, are small yellow-brown, brown, or rust-colored foci found in the spleen in patients with splenomegaly due to portal hypertension,^[1] as well as sickle cell disease. They consist of fibrous tissue with haemosiderin and calcium deposits, and probably form due to scarring at sites of small perivascular haemorrhages.^[2] They are visible on MRI scanning due to the presence of haemosiderin.^[3]

They can also be seen in atrial myxomas.

They are named after Charles Gandy and Carlos Gamna.

Notes and References

1. Book: Kuntz. Erwin. Kuntz. Hans-Dieter. Hepatology: Textbook and Atlas. 11 March 2009. Springer Science & Business Media. English . 9783540768395. 253. Prolonged portal hypertention sometimes leads to the formation of Gamna-Gandy nodules..
2. http://www.mondofacto.com/facts/dictionary?Gandy-Gamna+bodies Gandy-Gamna bodies
3. 2672093 . 10.1148/radiology.172.3.2672093 . 172 . Gamna-Gandy bodies of the spleen: evaluation with MR imaging . 1989 . Sagoh T, Itoh K, Togashi K, Shibata T, Nishimura K, Minami S, Asato R, Noma S, Fujisawa I, Yamashita K . Radiology . 3 . 685–7.