Galnon Explained

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GAL_R.^{[1] [2]} It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.^{[3] [4] [5] [6] [7]}

Notes and References

1. Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U . Anticonvulsant activity of a nonpeptide galanin receptor agonist . Proceedings of the National Academy of Sciences of the United States of America . 99 . 10 . 7136–41 . May 2002 . 12011470 . 124541 . 10.1073/pnas.102163499 . 2002PNAS...99.7136S . free .
2. Sollenberg U, Bartfai T, Langel U . Galnon--a low-molecular weight ligand of the galanin receptors . Neuropeptides . 39 . 3 . 161–3 . June 2005 . 15944006 . 10.1016/j.npep.2004.12.019 . 40987364 .
3. Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U . Regulation of feeding by galnon . Neuropeptides . 38 . 1 . 55–61 . February 2004 . 15003717 . 10.1016/j.npep.2004.01.001 . 38073212 .
4. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T . Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice . Neuropeptides . 39 . 3 . 249–51 . June 2005 . 15944018 . 10.1016/j.npep.2004.12.010 . 2142254 .
5. Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE . Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon . Neuropeptides . 41 . 5 . 307–20 . October 2007 . 17637475 . 10.1016/j.npep.2007.05.001 . 25988178 .
6. Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H . The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder . Biological Psychiatry . 65 . 5 . 383–91 . March 2009 . 19095221 . 10.1016/j.biopsych.2008.10.034 . 24537435 .
7. Narasimhaiah R, Kamens HM, Picciotto MR . Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice . Psychopharmacology . 204 . 1 . 95–102 . May 2009 . 19099295 . 2872184 . 10.1007/s00213-008-1438-7 .