Gaia Pigino Explained

Gaia Pigino
Nationality:Italian
Alma Mater:University of Siena (Diploma, PhD)
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Gaia Pigino is the Associate Head of the Structural Biology Research Center[1] and Leader of the "Pigino Group"[2] at the Human Technopole in Milan, Italy.[3]

Education

Gaia Pigino studied Natural Science at the University of Siena in Italy, finishing with a Diploma in 2002. From 2003 to 2007, she earned her Ph.D., working in the Department of Evolutionary Biology at the University of Siena, supervised by Prof Fabio Bernini and Prof Claudio Leonzio.[4]

Career and research

From 2007 to 2009, Gaia Pigino was employed at the Laboratory of Cryotechniques for Electron Microscopy in the Department of Evolutionary Biology of the University of Siena, under the guidance of Prof. Pietro Lupetti. she continued her postgraduate studies, also attending the prestigious Physiology course at the Marine Biological Laboratory (MBL) in Woods Hole (Massachusetts, USA). Subsequently, Gaia Pigino worked with Prof. Takashi Ishikawa at the ETH Zurich from 2009 to 2011 and then at the Paul Scherrer Institute from 2011 to 2012.[5] [6] [7] [8]

From 2012 to 2021, Gaia Pigino was a Research Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.[9] [10] [11] Since 2021, Gaia Pigino has been the Associate Head of the Structural Biology Research Center and Leader of the "Pigino Group" at the Human Technopole in Milan, Italy.[12] [13] [14]

Her research group operates at the intersection of structural and molecular cell biology, utilizing the most current methodologies from both areas to investigate the structure and dynamics of molecular machines that participate in the assembly and function of motile and primary cilia. Their overarching objective is to comprehend the fundamental molecular mechanisms of ciliary functions, as well as their malfunctions in ciliopathies.

Gaia Pigino is an internationally well-known biologist. Hence, she is frequently invited to workshops,[15] [16] seminars[17] and conferences[18] [19] [20] [21] in the field.

Awards and honours

Notes and References

  1. Web site: Structural Biology Website @ Humantechnopole .
  2. Web site: Pigino Group Website @ Humantechnopole .
  3. Web site: Gaia Pigino Profile @ Humantechnopole.
  4. Fine structure of the midgut and Malpighian papillae in Campodea (Monocampa) quilisi Silvestri, 1932 (Hexapoda, Diplura) with special reference to the metal composition and physiological significance of midgut intracellular electron-dense granules . 10.1016/j.tice.2005.02.001 . 2005 . Pigino . G. . Migliorini . M. . Paccagnini . E. . Bernini . F. . Leonzio . C. . Tissue and Cell . 37 . 3 . 223–232 . 15936358 .
  5. https://rupress.org/jcb/article/187/1/135/35530/Electron-tomographic-analysis-of-intraflagellar
  6. https://rupress.org/jcb/article/195/4/673/36643/Cryoelectron-tomography-of-radial-spokes-in-cilia
  7. 10.4161/bioa.20394 . Axonemal radial spokes . 2012 . Pigino . Gaia . Ishikawa . Takashi . Bioarchitecture . 2 . 2 . 50–58 . 22754630 . 3383722 .
  8. Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins . 10.1016/j.jsb.2012.02.012 . 2012 . Pigino . Gaia . Maheshwari . Aditi . Bui . Khanh Huy . Shingyoji . Chikako . Kamimura . Shinji . Ishikawa . Takashi . Journal of Structural Biology . 178 . 2 . 199–206 . 22406282 .
  9. Microtubule doublets are double-track railways for intraflagellar transport trains . 10.1126/science.aaf4594 . 2016 . Stepanek . Ludek . Pigino . Gaia . Science . 352 . 6286 . 721–724 . 27151870 . 2016Sci...352..721S . 206648246 .
  10. The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia . 10.1038/s41556-018-0213-1 . 2018 . Jordan . Mareike A. . Diener . Dennis R. . Stepanek . Ludek . Pigino . Gaia . Nature Cell Biology . 20 . 11 . 1250–1255 . 30323187 . 53024569 .
  11. 10.1038/s41594-020-0507-4 . The molecular structure of mammalian primary cilia revealed by cryo-electron tomography . 2020 . Kiesel . Petra . Alvarez Viar . Gonzalo . Tsoy . Nikolai . Maraspini . Riccardo . Gorilak . Peter . Varga . Vladimir . Honigmann . Alf . Pigino . Gaia . Nature Structural & Molecular Biology . 27 . 12 . 1115–1124 . 32989303 . 7610599 .
  12. https://www.cell.com/current-biology/fulltext/S0960-9822(21)00454-1
  13. In situ architecture of the ciliary base reveals the stepwise assembly of intraflagellar transport trains . 10.1126/science.abm6704 . 2022 . Van Den Hoek . Hugo . Klena . Nikolai . Jordan . Mareike A. . Alvarez Viar . Gonzalo . Righetto . Ricardo D. . Schaffer . Miroslava . Erdmann . Philipp S. . Wan . William . Geimer . Stefan . Plitzko . Jürgen M. . Baumeister . Wolfgang . Pigino . Gaia . Hamel . Virginie . Guichard . Paul . Engel . Benjamin D. . Science . 377 . 6605 . 543–548 . 35901159 . 2022Sci...377..543V . 251159956 .
  14. 10.1038/s41594-022-00905-5 . The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains . 2023 . Lacey . Samuel E. . Foster . Helen E. . Pigino . Gaia . Nature Structural & Molecular Biology . 30 . 5 . 584–593 . 36593313 . 10191852 .
  15. Web site: The Biophysical Society > Meetings & Events > Annual Meeting > 2024 Annual Meeting > Program > Scientific Sessions > Workshops .
  16. Web site: In situ Structural Biology: From Cryo-EM to Integrative Modelling – Virtual – Course and Conference Office .
  17. Web site: CSSB Seminar Series - GAIA PIGINO .
  18. Web site: Microtubules: From atoms to complex systems – Course and Conference Office .
  19. Web site: Enabling imaging across scales – Course and Conference Office .
  20. Web site: HOME - Cryo-electron Tomography .
  21. Web site: 2024 Three Dimensional Electron Microscopy Conference GRC .
  22. https://journals.biologists.com/jcs/article/130/6/1019/56694/Cell-scientist-to-watch-Gaia-Pigino
  23. Web site: Award for exceptional contributions to cell biology . 17 December 2018 .
  24. Web site: Self-organization of the cilium: The role of the tubulin code | CiliaTubulinCode Project | Fact Sheet | H2020 .
  25. https://erc.europa.eu/sites/default/files/document/file/erc_2018_cog_results_ls.pdf
  26. Web site: Funding for outstanding Research on Cilium and Retina . 29 November 2018 .
  27. Web site: Find people in the EMBO Communities .

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