Gadoxetic acid explained

Gadoxetic acid is a gadolinium-based MRI contrast agent.[1] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.[2]

Medical uses

It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.[3]

Pharmacokinetics

In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.[3]

Notes and References

  1. Koh DM, Ba-Ssalamah A, Brancatelli G, Fananapazir G, Fiel MI, Goshima S, Ju SH, Kartalis N, Kudo M, Lee JM, Murakami T, Seidensticker M, Sirlin CB, Tan CH, Wang J, Yoon JH, Zeng M, Zhou J, Taouli B . 6 . Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging . European Radiology . 31 . 8 . 5615–5628 . August 2021 . 33523304 . 8270799 . 10.1007/s00330-020-07637-4 .
  2. Web site: Eovist - Homepage . 22 March 2009 . 25 April 2009 . https://web.archive.org/web/20090425151035/http://imaging.bayerhealthcare.com/html/eovist/index.html . dead .
  3. Web site: Clinical pharmacology and biopharmaceutics review . Center for drug evaluation and research . 15 December 2022 . https://web.archive.org/web/20210512143335/https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022090s000_ClinPharmR.pdf . 12 May 2021.

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