| Fields: | Microbiology, Virology |
| Workplaces: | University of Bologna |
| Education: | Doctorate of Science, University of Bologna |
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| Awards: | Accademia Nazionale dei LinceiPasteur Institute, AthensFellowship in the American Academy of Microbiology |
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| Children: | Roberta Fiume[1] |
Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry.[2] She is a retired professor of virology from the University of Bologna, Italy.
Gabriella Camapadelli-Fiume completed her doctorate of science (Sc.D.) at the University of Bologna, Italy.[3] Her specialization in virology was also completed at the University of Bologna. Campadelli-Fiume primarily researches Herpes simplex virus (HSV), particularly how it enters, assembles, and exits the cell during an infection. In addition, she is interested in how HSV is induced to enter the exocytic pathway.
Herpes simplex virus consists of two types:
*Transmitted by oral contact, causes orolabial herpes (cold sores) and genital herpes[4]
*HSV-1 is the most common infection through the world. It is a lifelong infection with no cure. However, treatment is available to minimize its symptoms
*Sexually transmitted infection, can also cause genital herpes. HSV-2 has no cure, as well. It is a lifelong disease
*Increased risk of acquiring HIV with HSV-2
Herpesviruses
| Family | Herpesvirdae |
| Baltimore Classification | Group I |
| Genus Simplexvirus | Human Herpes simples virus type 1 |
| Genus Subfamily | Alphaherpesvirinae |
Campadelli-Fiume's discovered that nectin is the host cell receptor for HSV. She also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she identified the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.[5]
Gabriella Campadelli-Fiume took part in a study showing that glycoproteins gD, gB, and gH/gL permit herpes virus to enter cells and were involved in fusion. Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL. Rather, their interactions are made possible due to the multiple sites carried by gB. The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.[6]
Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields.[7] Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses,[8] her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers.[9] She has gained recent attention for applaudable women in science by the International Society of Antiviral Research (ISAR) that has featured her as a prominent woman scientist.[10] The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology. Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.
Gabriella Campadelli-Fiumme is an active member and leader in the scientific community.
Member of Health Research Committee from 2000-2006'[12]
Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus
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