GZMH explained

Granzyme H is a protein that in humans is encoded by the GZMH gene.^{[1] [2]}

Further reading

• Waterhouse NJ, Trapani JA . H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. . Trends Immunol. . 28 . 9 . 373–5 . 2007 . 17766182 . 10.1016/j.it.2007.08.001 .
• Llorens C, Martres MP, Baudry M, Schwartz JC . Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence. . Nature . 274 . 5671 . 603–5 . 1978 . 209336 . 10.1038/274603a0 . 1978Natur.274..603L . 4293645 .
• Heusel JW, Hanson RD, Silverman GA, Ley TJ . Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2. . J. Biol. Chem. . 266 . 10 . 6152–8 . 1991 . 10.1016/S0021-9258(18)38097-9 . 2007574 . free .
• Meier M . Cloning of a gene that encodes a new member of the human cytotoxic cell protease family . Biochemistry . 29 . 17 . 4042–9 . 1990 . 2193684 . 10.1021/bi00469a003 . vanc. Kwong PC . Frégeau CJ . 3 . Atkinson . E. A. . Burrington . M. . Ehrman . N. . Sorensen . O. . Lin . C. C. . Wilkins . J. .
• Hanson RD, Hohn PA, Popescu NC, Ley TJ . A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus . Proc. Natl. Acad. Sci. U.S.A. . 87 . 3 . 960–3 . 1990 . 2300587 . 10.1073/pnas.87.3.960 . 53389 . 1990PNAS...87..960H . free .
• Klein JL, Selvakumar A, Trapani JA, Dupont B . Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C) . Tissue Antigens . 35 . 5 . 220–8 . 1990 . 2402757 . 10.1111/j.1399-0039.1990.tb01787.x .
• MacIvor DM, Pham CT, Ley TJ . The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice . Blood . 93 . 3 . 963–73 . 1999 . 10.1182/blood.V93.3.963 . 9920846 .
• Edwards KM, Kam CM, Powers JC, Trapani JA . The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes . J. Biol. Chem. . 274 . 43 . 30468–73 . 1999 . 10521426 . 10.1074/jbc.274.43.30468 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ . Cell death induced by granzyme C . Blood . 101 . 8 . 3093–101 . 2003 . 12515723 . 10.1182/blood-2002-08-2485 . free .
• Sedelies KA . Discordant regulation of granzyme H and granzyme B expression in human lymphocytes . J. Biol. Chem. . 279 . 25 . 26581–7 . 2004 . 15069086 . 10.1074/jbc.M312481200 . vanc. Sayers TJ . Edwards KM . 3 . Chen . W . Pellicci . DG . Godfrey . DI . Trapani . JA . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andrade F . Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition . EMBO J. . 26 . 8 . 2148–57 . 2007 . 17363894 . 10.1038/sj.emboj.7601650 . 1852776 . vanc. Fellows E . Jenne DE . 3 . Rosen . Antony . Young . C S H .
• Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC . Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program . Blood . 110 . 2 . 544–52 . 2007 . 17409270 . 10.1182/blood-2006-10-051649 . free .

Notes and References

1. Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M . Structure and evolutionary origin of the human granzyme H gene . Int Immunol . 3 . 1 . 57–66 . Jul 1991 . 2049336 . 10.1093/intimm/3.1.57 .
2. Web site: Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX).