GX P2V explained
GX_P2V is a COVID-19 mutant strain that is fatal to humanized mice with the hACE2 gene. [1] The Chinese government has been performing tests on GX_P2V and has published a new study.[2] “This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2 related viruses," the paper's authors wrote. [3] GX_P2V infected the lungs, bones, eyes, tracheas and brains of the four lab mice tested.[4]
All four lab mice died rapidly after eight days due to severe vision impairment; particularly white eyes, severe weight loss, and poor movement. [5] [6]
Notes and References
- An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo . 2023. 10.1073/pnas.2207210120 . Liu . Kuo . Tang . Muxue . Xu . Wei . Meng . Xinfeng . Jin . Hengwei . Han . Maoying . Pu . Jing . Li . Yutang . Jiao . Fanke . Sun . Ruilin . Shen . Ruling . Lui . Kathy O. . Lu . Lu . Zhou . Bin . Proceedings of the National Academy of Sciences . 120 . 25 . e2207210120 . 37307455 . 10288645 . 2023PNAS..12007210L.
- An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) . Wei . Lai . Liu . Shuiqing . 2024-01-04 . Microbiology . 10.1101/2024.01.03.574008 . en . Lu . Shanshan . Luo . Shengdong . An . Xiaoping . Fan . Huahao . Chen . Weiwei . Li . Erguang . Tong . Yigang.
- Web site: Chinese lab crafts mutant COVID-19 strain with 100% kill rate in 'humanized' mice: 'Surprisingly' rapid death . N.Y. Post . 17 January 2024.
- News: 2024-01-17 . Chinese scientists create mutant COVID strain that kills mice . 2024-01-22 . Toronto Sun.
- Web site: White . Caleb . 2024-01-17 . What Is GX_P2V? Mutant Coronavirus Strain Kills Humanized Mice Within 8 Days [Study] ]. 2024-01-22 . The Science Times.
- Web site: Donlevy . Katherine . 2024-01-17 . Chinese lab crafts mutant COVID strain with 100% kill rate in ‘humanized’ mice: ‘Surprisingly’ rapid death . 2024-05-15 . New York Post.
