GUCY1B3 explained

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.^{[1] [2]}

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1^[3] and Endothelial NOS.^[3]

Further reading

• Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA . Guanylyl cyclases and signaling by cyclic GMP . Pharmacol. Rev. . 52 . 3 . 375–414 . 2000 . 10977868 .
• Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE . Heterogeneity in human soluble guanylate cyclase due to alternative splicing . FEBS Lett. . 290 . 1–2 . 157–8 . 1991 . 1680753 . 10.1016/0014-5793(91)81248-7 . 35130409 . free .
• Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G . Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33 . Hum. Genet. . 91 . 3 . 257–60 . 1993 . 8097486 . 10.1007/BF00218267 . 24237232 .
• Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD . cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue . J. Cell. Physiol. . 167 . 2 . 213–21 . 1996 . 8613461 . 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S . 25406282 . free .
• Zabel U, Weeger M, La M, Schmidt HH . Human soluble guanylate cyclase: functional expression and revised isoenzyme family . Biochem. J. . 335 . 1 . 51–7 . 1998 . 9742212 . 1219751 . 10.1042/bj3350051.
• Russwurm M, Wittau N, Koesling D . Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes . J. Biol. Chem. . 276 . 48 . 44647–52 . 2002 . 11572861 . 10.1074/jbc.M105587200 . free .
• Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD . Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase . Am. J. Physiol. Heart Circ. Physiol. . 285 . 2 . H669–78 . 2003 . 12676772 . 10.1152/ajpheart.01025.2002 .
• Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S . AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase . J. Biol. Chem. . 279 . 47 . 49346–54 . 2005 . 15381706 . 10.1074/jbc.M410565200 . free .
• Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ . Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction . Int. J. Impot. Res. . 18 . 5 . 432–7 . 2006 . 16528291 . 10.1038/sj.ijir.3901461 . free .

Notes and References

1. Giuili G, Scholl U, Bulle F, Guellaën G . Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain . FEBS Lett . 304 . 1 . 83–8 . Jul 1992 . 1352257 . 10.1016/0014-5793(92)80594-7 . 26032197 . free .
2. Web site: Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3.
3. Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD . Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase . Am. J. Physiol. Heart Circ. Physiol. . 285 . 2 . H669–78 . Aug 2003 . 12676772 . 10.1152/ajpheart.01025.2002 .