GUCY1A3 explained

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.^{[1] [2]}

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[2] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

Further reading

• Giuili G, Roechel N, Scholl U, etal . Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33. . Hum. Genet. . 91 . 3 . 257–60 . 1993 . 8097486 . 10.1007/BF00218267 . 24237232 .
• Papapetropoulos A, Cziraki A, Rubin JW, etal . cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue. . J. Cell. Physiol. . 167 . 2 . 213–21 . 1996 . 8613461 . 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S . 25406282 . free .
• Zabel U, Weeger M, La M, Schmidt HH . Human soluble guanylate cyclase: functional expression and revised isoenzyme family. . Biochem. J. . 335 . 1. 51–7 . 1998 . 9742212 . 10.1042/bj3350051. 1219751 .
• Zhou Y, Zheng JB, Gu X, etal . A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements? . Gene . 245 . 2 . 319–28 . 2000 . 10717483 . 10.1016/S0378-1119(00)00019-6 .
• Behrends S, Vehse K, Scholz H, etal . Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization. . Cytogenet. Cell Genet. . 88 . 3–4 . 204–5 . 2000 . 10828587 . 10.1159/000015548 . 5178613 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Saino M, Maruyama T, Sekiya T, etal . Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3 . Oncol. Rep. . 12 . 1 . 47–52 . 2005 . 15201957 . 10.3892/or.12.1.47.
• Meurer S, Pioch S, Wagner K, etal . AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase . J. Biol. Chem. . 279 . 47 . 49346–54 . 2005 . 15381706 . 10.1074/jbc.M410565200 . free.
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Giuili G, Scholl U, Bulle F, Guellaen G . Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain . FEBS Lett . 304 . 1 . 83–8 . Jul 1992 . 1352257 . 10.1016/0014-5793(92)80594-7 . 26032197 .
2. Web site: Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3.