GUCA1B explained

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene.^{[1] [2]} Alternative names:^[3]

• Guanylate cyclase activator 1B
• Retinal guanylyl cyclase activator protein p24

Biological Role

Guanylyl cyclase-activating protein 2 is proposed to play a role in dark adaptation.^[4] Under scotopic conditions, calcium ions bind to three putative EF-hand calcium binding motifs which reduces the protein's ability to stimulate guanylyl cyclase. This contributes to the maintained responsiveness of rod photoreceptors through hyperpolarizing them during sustained darkness.

Further reading

• Wiegand RC, Kato J, Huang MD, Fok KF, Kachur JF, Currie MG . Human guanylin: cDNA isolation, structure, and activity . FEBS Letters . 311 . 2 . 150–4 . October 1992 . 1327879 . 10.1016/0014-5793(92)81387-2 . 39983596 . free .
• de Sauvage FJ, Keshav S, Kuang WJ, Gillett N, Henzel W, Goeddel DV . Precursor structure, expression, and tissue distribution of human guanylin . Proceedings of the National Academy of Sciences of the United States of America . 89 . 19 . 9089–93 . October 1992 . 1409606 . 50070 . 10.1073/pnas.89.19.9089 . 1992PNAS...89.9089D . free .
• Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczyłko J, Surgucheva I, Baehr W, Milam AH, Palczewski K . 6 . Localization of guanylate cyclase-activating protein 2 in mammalian retinas . Proceedings of the National Academy of Sciences of the United States of America . 94 . 9 . 4727–32 . April 1997 . 9114059 . 20792 . 10.1073/pnas.94.9.4727 . 1997PNAS...94.4727O . free .
• Laura RP, Hurley JB . The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2 . Biochemistry . 37 . 32 . 11264–71 . August 1998 . 9698373 . 10.1021/bi9809674 .
• Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K . Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1 . Biochemistry . 38 . 5 . 1387–93 . February 1999 . 9931003 . 10.1021/bi982512k .
• Payne AM, Downes SM, Bessant DA, Plant C, Moore T, Bird AC, Bhattacharya SS . Genetic analysis of the guanylate cyclase activator 1B (GUCA1B) gene in patients with autosomal dominant retinal dystrophies . Journal of Medical Genetics . 36 . 9 . 691–3 . September 1999 . 10507726 . 1734430 . 10.1136/jmg.36.9.691 .
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . 6 . Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts . Molecular Vision . 8 . 196–204 . June 2002 . 12107411 .
• Sato M, Nakazawa M, Usui T, Tanimoto N, Abe H, Ohguro H . Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies . Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie . 243 . 3 . 235–42 . March 2005 . 15452722 . 10.1007/s00417-004-1015-7 . 23347858 .

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview

Notes and References

1. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W . 6 . The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1) . Genomics . 39 . 3 . 312–22 . February 1997 . 9119368 . 10.1006/geno.1996.4513 . free .
2. Web site: Entrez Gene: GUCA1B guanylate cyclase activator 1B (retina).
3. Web site: GUCA1B - Guanylyl cyclase-activating protein 2 - Bos taurus (Bovine) - GUCA1B gene & protein. www.uniprot.org. en. 2017-10-09.
4. Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K . Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods . Proceedings of the National Academy of Sciences of the United States of America . 91 . 9 . 4014–8 . April 1994 . 7909609 . 10.1073/pnas.91.9.4014 . 43713 . 1994PNAS...91.4014G . free .