GUCA1A explained

Guanylyl cyclase-activating protein 1 is an enzyme that in humans is encoded by the GUCA1A gene.^{[1] [2]}

Further reading

• Subbaraya I, Ruiz CC, Helekar BS, etal . Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. . J. Biol. Chem. . 269 . 49 . 31080–9 . 1995 . 10.1016/S0021-9258(18)47393-0 . 7983048 . free .
• Surguchov A, Bronson JD, Banerjee P, etal . The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). . Genomics . 39 . 3 . 312–22 . 1997 . 9119368 . 10.1006/geno.1996.4513 . free .
• Dizhoor AM, Boikov SG, Olshevskaya EV . Constitutive activation of photoreceptor guanylate cyclase by Y99C mutant of GCAP-1. Possible role in causing human autosomal dominant cone degeneration. . J. Biol. Chem. . 273 . 28 . 17311–4 . 1998 . 9651312 . 10.1074/jbc.273.28.17311 . free .
• Sokal I, Li N, Surgucheva I, etal . GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. . Mol. Cell . 2 . 1 . 129–33 . 1998 . 9702199 . 10.1016/S1097-2765(00)80121-5 . free .
• Sokal I, Li N, Verlinde CL, etal . Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). . Biochim. Biophys. Acta . 1498 . 2–3 . 233–51 . 2001 . 11108966 . 10.1016/S0167-4889(00)00099-9. free .
• Downes SM, Holder GE, Fitzke FW, etal . Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1 . Arch. Ophthalmol. . 119 . 1 . 96–105 . 2001 . 11146732 . 10.1001/archopht.119.11.1667. free .
• Wilkie SE, Li Y, Deery EC, etal . Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy . Am. J. Hum. Genet. . 69 . 3 . 471–80 . 2001 . 11484154 . 10.1086/323265 . 1235478 .
• Hwang JY, Koch KW . Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and protein-2 . Biochemistry . 41 . 43 . 13021–8 . 2002 . 12390029 . 10.1021/bi026618y .
• Hwang JY, Koch KW . The myristoylation of the neuronal Ca2+ -sensors guanylate cyclase-activating protein 1 and 2 . Biochim. Biophys. Acta . 1600 . 1–2 . 111–7 . 2002 . 12445466 . 10.1016/S1570-9639(02)00451-X.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Pennesi ME, Howes KA, Baehr W, Wu SM . Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice . Proc. Natl. Acad. Sci. U.S.A. . 100 . 11 . 6783–8 . 2003 . 12732716 . 10.1073/pnas.1130102100 . 164524 . 2003PNAS..100.6783P . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Peshenko IV, Moiseyev GP, Olshevskaya EV, Dizhoor AM . Factors that determine Ca2+ sensitivity of photoreceptor guanylyl cyclase. Kinetic analysis of the interaction between the Ca2+-bound and the Ca2+-free guanylyl cyclase activating proteins (GCAPs) and recombinant photoreceptor guanylyl cyclase 1 (RetGC-1) . Biochemistry . 43 . 43 . 13796–804 . 2004 . 15504042 . 10.1021/bi048943m .
• Nishiguchi KM, Sokal I, Yang L, etal . A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration . Invest. Ophthalmol. Vis. Sci. . 45 . 11 . 3863–70 . 2004 . 15505030 . 10.1167/iovs.04-0590 . 1475955 .
• Jiang L, Katz BJ, Yang Z, etal . Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A) . Mol. Vis. . 11 . 143–51 . 2005 . 15735604 .
• Sokal I, Dupps WJ, Grassi MA, etal . A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD) . Invest. Ophthalmol. Vis. Sci. . 46 . 4 . 1124–32 . 2005 . 15790869 . 10.1167/iovs.04-1431 . 1352313 .
• Michaelides M, Wilkie SE, Jenkins S, etal . Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy . Ophthalmology . 112 . 8 . 1442–7 . 2005 . 15953638 . 10.1016/j.ophtha.2005.02.024 .

Notes and References

1. Payne AM, Downes SM, Bessant DA, Taylor R, Holder GE, Warren MJ, Bird AC, Bhattacharya SS . A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1 . Hum Mol Genet . 7 . 2 . 273–7 . Mar 1998 . 9425234 . 10.1093/hmg/7.2.273 .
2. Web site: Entrez Gene: GUCA1A guanylate cyclase activator 1A (retina).