| GTP diphosphokinase | |
| Ec Number: | 2.7.6.5 |
| Cas Number: | 63690-89-1 |
| Go Code: | 0008728 |
In enzymology, a GTP diphosphokinase is an enzyme that catalyzes the chemical reaction
ATP + GTP
\rightleftharpoons
Thus, the two substrates of this enzyme are ATP and GTP, whereas its two products are AMP and guanosine 3'-diphosphate 5'-triphosphate.
This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:GTP 3'-diphosphotransferase. Other names in common use include stringent factor, guanosine 3',5'-polyphosphate synthase, GTP pyrophosphokinase, ATP-GTP 3'-diphosphotransferase, guanosine 5',3'-polyphosphate synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, guanosine pentaphosphate synthetase, GPSI, and GPSII. This enzyme participates in purine metabolism.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes,,, and .