GTPBP1 explained

GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene.^{[1] [2]}

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mice, where disruption of the gene for that protein had no observable phenotype.

Further reading

• Goretzki L, Mueller BM . Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein . Biochem. J. . 336 . 2. 381–6 . 1999 . 9820815 . 10.1042/bj3360381. 1219882 .
• Dunham I, Shimizu N, Roe BA, etal . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Kudo H, Senju S, Mitsuya H, Nishimura Y . Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase . Biochem. Biophys. Res. Commun. . 272 . 2 . 456–65 . 2000 . 10833435 . 10.1006/bbrc.2000.2763 .
• Senju S, Iyama K, Kudo H, etal . Immunocytochemical analyses and targeted gene disruption of GTPBP1 . Mol. Cell. Biol. . 20 . 17 . 6195–200 . 2000 . 10938096 . 10.1128/MCB.20.17.6195-6200.2000 . 86094 .
• Zhang QH, Ye M, Wu XY, etal . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Senju S, Nishimura Y . Identification of human and mouse GP-1, a putative member of a novel G-protein family . Biochem Biophys Res Commun . 231 . 2 . 360–4 . Apr 1997 . 9070279 . 10.1006/bbrc.1997.6103 .
2. Web site: Entrez Gene: GTPBP1 GTP binding protein 1.