GTF2A1 explained

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.^{[1] [2]}

Interactions

GTF2A1 has been shown to interact with TATA binding protein^{[3] [4] [5] [6] [7]} and TBPL1.^{[8] [9]}

See also

• Transcription Factor II A

References

Further reading

• Ha I, Lane WS, Reinberg D . Cloning of a human gene encoding the general transcription initiation factor IIB . Nature . 352 . 6337 . 689–95 . Aug 1991 . 1876184 . 10.1038/352689a0 . 1991Natur.352..689H . 4267950 .
• DeJong J, Bernstein R, Roeder RG . Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription . Proceedings of the National Academy of Sciences of the United States of America . 92 . 8 . 3313–7 . Apr 1995 . 7724559 . 42156 . 10.1073/pnas.92.8.3313 . 1995PNAS...92.3313D . free .
• Ozer J, Moore PA, Bolden AH, Lee A, Rosen CA, Lieberman PM . Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription . Genes & Development . 8 . 19 . 2324–35 . Oct 1994 . 7958899 . 10.1101/gad.8.19.2324 . free .
• Sun X, Ma D, Sheldon M, Yeung K, Reinberg D . Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription . Genes & Development . 8 . 19 . 2336–48 . Oct 1994 . 7958900 . 10.1101/gad.8.19.2336 . free .
• Ge H, Roeder RG . The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein . The Journal of Biological Chemistry . 269 . 25 . 17136–40 . Jun 1994 . 10.1016/S0021-9258(17)32531-0 . 8006019 . free .
• Ma D, Watanabe H, Mermelstein F, Admon A, Oguri K, Sun X, Wada T, Imai T, Shiroya T, Reinberg D . Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription . Genes & Development . 7 . 11 . 2246–57 . Nov 1993 . 8224850 . 10.1101/gad.7.11.2246 . free .
• Tang H, Sun X, Reinberg D, Ebright RH . Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex . Proceedings of the National Academy of Sciences of the United States of America . 93 . 3 . 1119–24 . Feb 1996 . 8577725 . 40041 . 10.1073/pnas.93.3.1119 . 1996PNAS...93.1119T . free .
• Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN . Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex . Journal of Virology . 70 . 8 . 5503–10 . Aug 1996 . 8764062 . 190508 . 10.1128/JVI.70.8.5503-5510.1996.
• Zhou Q, Sharp PA . Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat . Science . 274 . 5287 . 605–10 . Oct 1996 . 8849451 . 10.1126/science.274.5287.605 . 1996Sci...274..605Z . 13266489 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM . Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding . The Journal of Biological Chemistry . 273 . 23 . 14293–300 . Jun 1998 . 9603936 . 10.1074/jbc.273.23.14293 . free .
• Yokomori K, Verrijzer CP, Tjian R . An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription . Proceedings of the National Academy of Sciences of the United States of America . 95 . 12 . 6722–7 . Jun 1998 . 9618479 . 22611 . 10.1073/pnas.95.12.6722 . 1998PNAS...95.6722Y . free .
• Na SY, Choi HS, Kim JW, Na DS, Lee JW . Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor . The Journal of Biological Chemistry . 273 . 47 . 30933–8 . Nov 1998 . 9812988 . 10.1074/jbc.273.47.30933 . free .
• Upadhyaya AB, Lee SH, DeJong J . Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis . The Journal of Biological Chemistry . 274 . 25 . 18040–8 . Jun 1999 . 10364255 . 10.1074/jbc.274.25.18040 . free .
• Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW . Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation . Molecular and Cellular Biology . 19 . 9 . 6323–32 . Sep 1999 . 10454579 . 84603 . 10.1128/mcb.19.9.6323.
• Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW . A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo . The Journal of Biological Chemistry . 274 . 48 . 34283–93 . Nov 1999 . 10567404 . 10.1074/jbc.274.48.34283 . free .
• Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG . Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13720–5 . Nov 1999 . 10570139 . 24131 . 10.1073/pnas.96.24.13720 . 1999PNAS...9613720T . free .
• Solow S, Salunek M, Ryan R, Lieberman PM . Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity . The Journal of Biological Chemistry . 276 . 19 . 15886–92 . May 2001 . 11278496 . 10.1074/jbc.M009385200 . free .
• Xing J, Sheppard HM, Corneillie SI, Liu X . p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction . Molecular and Cellular Biology . 21 . 11 . 3652–61 . Jun 2001 . 11340159 . 86992 . 10.1128/MCB.21.11.3652-3661.2001 .

Notes and References

1. DeJong J, Roeder RG . A single cDNA, hTFIIA/alpha, encodes both the p35 and p19 subunits of human TFIIA . Genes & Development . 7 . 11 . 2220–34 . Nov 1993 . 8224848 . 10.1101/gad.7.11.2220 . free .
2. Web site: Entrez Gene: GTF2A1 general transcription factor IIA, 1, 19/37kDa.
3. DeJong J, Bernstein R, Roeder RG . Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription . Proceedings of the National Academy of Sciences of the United States of America . 92 . 8 . 3313–7 . Apr 1995 . 7724559 . 42156 . 10.1073/pnas.92.8.3313 . 1995PNAS...92.3313D . free .
4. Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B . Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II . The Journal of Biological Chemistry . 276 . 42 . 38652–7 . Oct 2001 . 11509574 . 10.1074/jbc.M106422200 . 4492724. free .
5. Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman PM . Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding . The Journal of Biological Chemistry . 273 . 23 . 14293–300 . Jun 1998 . 9603936 . 10.1074/jbc.273.23.14293 . free .
6. Solow S, Salunek M, Ryan R, Lieberman PM . Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity . The Journal of Biological Chemistry . 276 . 19 . 15886–92 . May 2001 . 11278496 . 10.1074/jbc.M009385200 . free .
7. Sun X, Ma D, Sheldon M, Yeung K, Reinberg D . Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription . Genes & Development . 8 . 19 . 2336–48 . Oct 1994 . 7958900 . 10.1101/gad.8.19.2336 . free .
8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
9. Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG . Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13720–5 . Nov 1999 . 10570139 . 24131 . 10.1073/pnas.96.24.13720 . 1999PNAS...9613720T . free .