GRWD1 explained

Glutamate-rich WD repeat-containing protein 1 is a WD40 repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has known functions in regulating chromatin openness and loading of MCM helicase.^{[1] [2]}

Further reading

• Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Research . 8 . 6 . 319–27 . Dec 2001 . 11853319 . 10.1093/dnares/8.6.319 .
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ . Functional proteomic analysis of human nucleolus . Molecular Biology of the Cell . 13 . 11 . 4100–9 . Nov 2002 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 .
• Trzcińska AM, Girstun A, Piekiełko A, Kowalska-Loth B, Staroń K . Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display . Molecular Biology Reports . 29 . 4 . 347–52 . Dec 2002 . 12549820 . 10.1023/A:1021237021338 . 9602116 .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . Feb 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . Jan 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H . CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation . Nature Cell Biology . 8 . 11 . 1277–83 . Nov 2006 . 17041588 . 10.1038/ncb1490 . 22180568 . 10397/34293 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Gratenstein K, Heggestad AD, Fortun J, Notterpek L, Pestov DG, Fletcher BS . The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis . Genomics . 85 . 6 . 762–73 . Jun 2005 . 15885502 . 10.1016/j.ygeno.2005.02.010 .
2. Web site: Entrez Gene: GRWD1 glutamate-rich WD repeat containing 1.