GRL-0617 explained
| Drug Name: | GRL-0617 |
| C: | 20 |
| H: | 20 |
| N: | 2 |
| O: | 1 |
| Iupac Name: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide |
| Cas Number: | 1093070-16-6 |
| Unii: | GRL-0617 |
| Chebi: | 167176 |
| Chembl: | 549695 |
| Chemspiderid: | 24617535 |
| Drugbank: | DB08656 |
| Iuphar Ligand: | 11078 |
| Pubchem: | 24941262 |
| Smiles: | CC1=C(C=C(C=C1)N)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32 |
| Stdinchi: | 1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1 |
| Stdinchikey: | UVERBUNNCOKGNZ-CQSZACIVSA-N |
GRL-0617 is a drug which is one of the first compounds discovered that acts as a selective small-molecule inhibitor of the protease enzyme papain-like protease (PLpro) found in some human pathogenic viruses, including the coronavirus SARS-CoV-2. It has been shown to inhibit viral replication in silico [1] and in vitro.[2] [3] [4] [5]
See also
Notes and References
- Shanker AK, Bhanu D, Alluri A, Gupta S . Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties . New Journal of Chemistry . 44 . 22 . 9202–9212. May 2020 . 10.1039/D0NJ00974A . 218938798 .
- Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I . 6 . Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity . Nature . 587 . 7835 . 657–662 . November 2020 . 32726803 . 10.1038/s41586-020-2601-5 . 7116779 . 2020Natur.587..657S .
- Hajbabaie R, Harper MT, Rahman T . Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease . Molecules . 26 . 4 . February 2021 . 1134 . 33672721 . 10.3390/molecules26041134 . 7924369 . free .
- Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, Drury LS, Milligan JC, Zeisner TU, Zeng J, Weissmann F, Canal B, Bineva-Todd G, Howell M, O'Reilly N, Beale R, Kulathu Y, Labib K, Diffley JF . 6 . Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease . The Biochemical Journal . 478 . 13 . 2517–2531 . July 2021 . 34198325 . 10.1042/BCJ20210244 . 8286840 .
- Xiang R, Yu Z, Wang Y, Wang L, Huo S, Li Y, Liang R, Hao Q, Ying T, Gao Y, Yu F, Jiang S . 6 . Recent advances in developing small-molecule inhibitors against SARS-CoV-2 . Acta Pharmaceutica Sinica B . July 2021 . 12 . 4 . 1591–1623 . 34249607 . 10.1016/j.apsb.2021.06.016 . 8260826 .
