GRIP domain explained

Symbol:	GRIP
GRIP domain
Pfam:	PF01465
Interpro:	IPR000237
Scop:	1upt

In molecular biology, the GRIP domain is a conserved protein domain. The GRIP (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. It contains a completely conserved tyrosine residue.^{[1] [2] [3]}

Notes and References

1. Munro S, Nichols BJ . The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins . Curr. Biol. . 9 . 7 . 377–80 . April 1999 . 10209120 . 10.1016/S0960-9822(99)80166-3. 14905585 . free .
2. Barr FA . A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins . Curr. Biol. . 9 . 7 . 381–4 . April 1999 . 10209123 . 10.1016/S0960-9822(99)80167-5. 14404566 . free .
3. Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA . A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins . Curr. Biol. . 9 . 7 . 385–8 . April 1999 . 10209125 . 10.1016/S0960-9822(99)80168-7. 14342088 . free .