GRIPAP1 explained

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.^{[1] [2]}

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM]^[2]

Interactions

GRIPAP1 has been shown to interact with GRIP1.

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O . Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain . DNA Res. . 6 . 5 . 329–36 . 1999 . 10574461 . 10.1093/dnares/6.5.329 . free .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP . Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex . J. Biol. Chem. . 277 . 4 . 2396–405 . 2002 . 11704662 . 10.1074/jbc.M106312200 . free .
• Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK . The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs . J. Biol. Chem. . 277 . 18 . 15221–4 . 2002 . 11891216 . 10.1074/jbc.C200112200 . free . 2262/89271 . free .
• Ye B, Sugo N, Hurn PD, Huganir RL . Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody . Neuroscience . 114 . 1 . 217–27 . 2002 . 12207967 . 10.1016/S0306-4522(02)00142-2 . 39432674 .
• Coutts AS, MacKenzie E, Griffith E, Black DM . TES is a novel focal adhesion protein with a role in cell spreading . J. Cell Sci. . 116 . Pt 5 . 897–906 . 2003 . 12571287 . 10.1242/jcs.00278 . free .
• Nakata A, Ito T, Nagata M, Hori S, Sekimizu K . GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 . Genes Cells . 9 . 11 . 1125–35 . 2004 . 15507123 . 10.1111/j.1365-2443.2004.00795.x . free .
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Stinton LM, Selak S, Fritzler MJ . Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes . Clin. Immunol. . 116 . 2 . 108–17 . 2005 . 15897011 . 10.1016/j.clim.2005.03.021 .

Notes and References

1. Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL . GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex . Neuron . 26 . 3 . 603–17 . Aug 2000 . 10896157 . 10.1016/S0896-6273(00)81198-8 . free .
2. Web site: Entrez Gene: GRIPAP1 GRIP1 associated protein 1.