GRIN3B explained

Glutamate [NMDA] receptor subunit 3B is a protein that in humans is encoded by the GRIN3B gene.^[1]

See also

• NMDA receptor

Further reading

• Schröder HC, Perovic S, Kavsan V, etal . Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. . Neurotoxicology . 19 . 4–5 . 683–8 . 1998 . 9745929 .
• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH. Mary B. Kennedy . Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 . Science . 269 . 5231 . 1737–40 . 1995 . 7569905 . 10.1126/science.7569905 . 1995Sci...269.1737K .
• Magnuson DS, Knudsen BE, Geiger JD, etal . Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity . Ann. Neurol. . 37 . 3 . 373–80 . 1995 . 7695237 . 10.1002/ana.410370314 . 24405132 .
• Lannuzel A, Lledo PM, Lamghitnia HO, etal . HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons . Eur. J. Neurosci. . 7 . 11 . 2285–93 . 1996 . 8563977 . 10.1111/j.1460-9568.1995.tb00649.x . 27201873 .
• Corasaniti MT, Melino G, Navarra M, etal . Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase . Neurodegeneration . 4 . 3 . 315–21 . 1996 . 8581564 . 10.1016/1055-8330(95)90021-7.
• Pittaluga A, Pattarini R, Severi P, Raiteri M . Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120 . AIDS . 10 . 5 . 463–8 . 1996 . 8724036 . 10.1097/00002030-199605000-00003 . 1669986 .
• Wu P, Price P, Du B, etal . Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons . NeuroReport . 7 . 5 . 1045–9 . 1996 . 8804048 . 10.1097/00001756-199604100-00018 . 21018147 .
• Bennett BA, Rusyniak DE, Hollingsworth CK . HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures . Brain Res. . 705 . 1–2 . 168–76 . 1996 . 8821747 . 10.1016/0006-8993(95)01166-8 . 32822686 .
• Toggas SM, Masliah E, Mucke L . Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine . Brain Res. . 706 . 2 . 303–7 . 1996 . 8822372 . 10.1016/0006-8993(95)01197-8 . 44260060 .
• Dreyer EB, Lipton SA . The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid . Eur. J. Neurosci. . 7 . 12 . 2502–7 . 1996 . 8845955 . 10.1111/j.1460-9568.1995.tb01048.x . 7370984 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Raber J, Toggas SM, Lee S, etal . Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase . Virology . 226 . 2 . 362–73 . 1997 . 8955056 . 10.1006/viro.1996.0664 . free .
• New DR, Maggirwar SB, Epstein LG, etal . HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism . J. Biol. Chem. . 273 . 28 . 17852–8 . 1998 . 9651389 . 10.1074/jbc.273.28.17852 . free .
• Wang P, Barks JD, Silverstein FS . Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats . Neuroscience . 88 . 2 . 585–97 . 1999 . 10197777 . 10.1016/S0306-4522(98)00242-5 . 28927942 .
• Howard SA, Nakayama AY, Brooke SM, Sapolsky RM . Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures . Exp. Neurol. . 158 . 1 . 164–70 . 1999 . 10448428 . 10.1006/exnr.1999.7080 . 7598117 . free .
• Xin KQ, Hamajima K, Hattori S, etal . Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system . AIDS Res. Hum. Retroviruses . 15 . 16 . 1461–7 . 1999 . 10555109 . 10.1089/088922299309973 .
• Haughey NJ, Nath A, Mattson MP, etal . HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity . J. Neurochem. . 78 . 3 . 457–67 . 2001 . 11483648 . 10.1046/j.1471-4159.2001.00396.x . 25641791 .
• Bonavia R, Bajetto A, Barbero S, etal . HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons . Biochem. Biophys. Res. Commun. . 288 . 2 . 301–8 . 2001 . 11606043 . 10.1006/bbrc.2001.5743 .
• Nishi M, Hinds H, Lu HP, etal . Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner . J. Neurosci. . 21 . 23 . RC185 . 2002 . 11717388 . 10.1523/JNEUROSCI.21-23-j0003.2001. 6763906 .

Notes and References

1. Web site: Entrez Gene: GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B.