GRIK3 explained

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.^{[1] [2]}

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.

See also

• Kainate receptor

Further reading

• Nutt SL, Hoo KH, Rampersad V, etal . Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites. . Recept. Channels . 2 . 4 . 315–26 . 1995 . 7719709 .
• Roche KW, Raymond LA, Blackstone C, Huganir RL . Transmembrane topology of the glutamate receptor subunit GluR6. . J. Biol. Chem. . 269 . 16 . 11679–82 . 1994 . 10.1016/S0021-9258(17)32623-6 . 8163463 . free .
• Ripellino JA, Neve RL, Howe JR . Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. . Neuroscience . 82 . 2 . 485–97 . 1998 . 9466455 . 10.1016/S0306-4522(97)00296-0 . 23219004 . free .
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . free .
• Schiffer HH, Swanson GT, Masliah E, Heinemann SF . Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. . J. Neurosci. . 20 . 24 . 9025–33 . 2001 . 11124978 . 10.1523/JNEUROSCI.20-24-09025.2000. 6773004 .
• Enz R . The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. . FEBS Lett. . 514 . 2–3 . 184–8 . 2002 . 11943148 . 10.1016/S0014-5793(02)02361-X . 44474808 .
• Begni S, Popoli M, Moraschi S, etal . Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. . Mol. Psychiatry . 7 . 4 . 416–8 . 2002 . 11986986 . 10.1038/sj.mp.4000987 . free .
• Delorme R, Krebs MO, Chabane N, etal . Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder. . NeuroReport . 15 . 4 . 699–702 . 2004 . 15094479 . 10.1097/00001756-200403220-00025 . 29816578 .
• Preuss UW, Zill P, Koller G, etal . Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics. . Pharmacogenomics J. . 6 . 1 . 34–41 . 2006 . 16314883 . 10.1038/sj.tpj.6500343 . 5874096 .
• Samochowiec J, Grzywacz A, Kucharska-Mazur J, etal . Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence. . Neurosci. Lett. . 396 . 2 . 159–62 . 2006 . 16356644 . 10.1016/j.neulet.2005.11.030 . 23136504 .
• Schiffer HH, Heinemann SF . Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 144 . 1 . 20–6 . 2007 . 16958029 . 10.1002/ajmg.b.30374 . free .
• Kim JM, Lee KH, Jeon YJ, etal . Identification of genes related to Parkinson's disease using expressed sequence tags. . DNA Res. . 13 . 6 . 275–86 . 2007 . 17213182 . 10.1093/dnares/dsl016 . free .

Notes and References

1. Puranam RS, Eubanks JH, Heinemann SF, McNamara JO . Chromosomal localization of gene for human glutamate receptor subunit-7 . Somat Cell Mol Genet . 19 . 6 . 581–8 . Apr 1994 . 8128318 . 10.1007/BF01233385 . 44460126 .
2. Web site: Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3.