GRAMD4 explained

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.^{[1] [2]}

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.^[3]

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Mol. Med. . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• John K, Alla V, Meier C, Pützer BM . GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria . Cell Death Differ. . 18 . 5 . 874–86 . 2011 . 21127500 . 3131914 . 10.1038/cdd.2010.153 .

Notes and References

1. Web site: Entrez Gene: GRAM domain containing 4. 2017-05-16.
2. Web site: RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein. 2020-03-07.
3. Stanelle J, Tu-Rapp H, Pützer BM . A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53 . Cell Death Differ. . 12 . 4 . 347–57 . 2005 . 15565177 . 10.1038/sj.cdd.4401532 . 24578301 .