GR-127935 explained

GR-127935 is a drug which acts as a selective antagonist at the serotonin receptors 5-HT1B and 5-HT1D.[1] It has little effect when given by itself but blocks the antiaggressive effect of 5-HT1B agonists,[2] and alters release of serotonin in the brain,[3] as well as reducing drug-seeking behaviour in cocaine addicted rats.[4]

See also

Notes and References

  1. Skingle M, Beattie DT, Scopes DI, Starkey SJ, Connor HE, Feniuk W, Tyers MB . GR127935: a potent and selective 5-HT1D receptor antagonist . Behavioural Brain Research . 73 . 1–2 . 157–61 . 1996 . 8788495 . 10.1016/0166-4328(96)00089-7. 34394584 .
  2. Bannai M, Fish EW, Faccidomo S, Miczek KA . Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice . Psychopharmacology . 193 . 2 . 295–304 . August 2007 . 17440711 . 10.1007/s00213-007-0780-5 . 6766784 .
  3. Rex A, Voigt JP, Wicke KM, Fink H . In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs . Pharmacology Biochemistry and Behavior . 88 . 3 . 196–204 . January 2008 . 17888505 . 10.1016/j.pbb.2007.07.016 . 26577695 .
  4. Przegaliński E, Gołda A, Filip M . Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats . Pharmacological Reports . 60 . 6 . 798–810 . 2008 . 19211971 .

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