GPSM1 explained

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.^{[1] [2] [3]}

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]

Further reading

• Natochin M, Lester B, Peterson YK, etal . AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin . J. Biol. Chem. . 275 . 52 . 40981–5 . 2001 . 11024022 . 10.1074/jbc.M006478200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . free . 2002PNAS...9916899M .
• Pattingre S, De Vries L, Bauvy C, etal . The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells . J. Biol. Chem. . 278 . 23 . 20995–1002 . 2003 . 12642577 . 10.1074/jbc.M300917200 . free .
• Kaushik R, Yu F, Chia W, etal . Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression . Mol. Biol. Cell . 14 . 8 . 3144–55 . 2004 . 12925752 . 10.1091/mbc.E03-04-0212 . 181556 .
• Adhikari A, Sprang SR . Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1 . J. Biol. Chem. . 278 . 51 . 51825–32 . 2004 . 14530282 . 10.1074/jbc.M306300200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Du Q, Macara IG . Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins . Cell . 119 . 4 . 503–16 . 2004 . 15537540 . 10.1016/j.cell.2004.10.028 . 12900159 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Izaki T, Kamakura S, Kohjima M, Sumimoto H . Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3 . Biochem. Biophys. Res. Commun. . 341 . 4 . 1001–6 . 2006 . 16458856 . 10.1016/j.bbrc.2006.01.050 .

Notes and References

1. Pizzinat N, Takesono A, Lanier SM . Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains . J Biol Chem . 276 . 20 . 16601–10 . May 2001 . 11278352 . 10.1074/jbc.M007573200 . free .
2. Peterson YK, Bernard ML, Ma H, ((Hazard S III)), Graber SG, Lanier SM . Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3 . J Biol Chem . 275 . 43 . 33193–6 . Nov 2000 . 10969064 . 10.1074/jbc.C000509200 . free .
3. Web site: Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans).