GPS1 explained

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene.^[1]

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[2]

Further reading

• Wolf DA, Zhou C, Wee S . The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? . Nat. Cell Biol. . 5 . 12 . 1029–33 . 2004 . 14647295 . 10.1038/ncb1203-1029 . 37458780 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Spain BH, Bowdish KS, Pacal AR, etal . Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells . Mol. Cell. Biol. . 16 . 12 . 6698–706 . 1997 . 8943324 . 10.1128/mcb.16.12.6698. 231672 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Wei N, Tsuge T, Serino G, etal . The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex . Curr. Biol. . 8 . 16 . 919–22 . 1998 . 9707402 . 10.1016/S0960-9822(07)00372-7 . 13873982 . free . 1998CBio....8..919W .
• Tsuge T, Matsui M, Wei N . The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain . J. Mol. Biol. . 305 . 1 . 1–9 . 2001 . 11114242 . 10.1006/jmbi.2000.4288 .
• Bech-Otschir D, Kraft R, Huang X, etal . COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system . EMBO J. . 20 . 7 . 1630–9 . 2001 . 11285227 . 10.1093/emboj/20.7.1630 . 145508 .
• Lyapina S, Cope G, Shevchenko A, etal . Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome . Science . 292 . 5520 . 1382–5 . 2001 . 11337588 . 10.1126/science.1059780 . 2001Sci...292.1382L . 14224920 .
• Hoareau Alves K, Bochard V, Réty S, Jalinot P . Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome . FEBS Lett. . 527 . 1–3 . 15–21 . 2002 . 12220626 . 10.1016/S0014-5793(02)03147-2 . 39308598 . free .
• Sun Y, Wilson MP, Majerus PW . Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1 . J. Biol. Chem. . 277 . 48 . 45759–64 . 2003 . 12324474 . 10.1074/jbc.M208709200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Serino G, Su H, Peng Z, etal . Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex . Plant Cell . 15 . 3 . 719–31 . 2003 . 12615944 . 10.1105/tpc.009092 . 150025 .
• Uhle S, Medalia O, Waldron R, etal . Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome . EMBO J. . 22 . 6 . 1302–12 . 2003 . 12628923 . 10.1093/emboj/cdg127 . 151059 .
• Groisman R, Polanowska J, Kuraoka I, etal . The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage . Cell . 113 . 3 . 357–67 . 2003 . 12732143 . 10.1016/S0092-8674(03)00316-7 . 11639677 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Wang Y, Lu C, Wei H, etal . Hepatopoietin interacts directly with COP9 signalosome and regulates AP-1 activity . FEBS Lett. . 572 . 1–3 . 85–91 . 2004 . 15304329 . 10.1016/j.febslet.2004.07.012 . 23573449 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .

Notes and References

1. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W . A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits . FASEB J . 12 . 6 . 469–78 . Apr 1998 . 9535219 . 10.1096/fasebj.12.6.469. free . 25424324 .
2. Web site: Entrez Gene: GPS1 G protein pathway suppressor 1.