GPRC5B explained

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade.

See also

• Retinoic acid-inducible orphan G protein-coupled receptor

Further reading

• Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN . Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) . Genomics . 67 . 1 . 8–18 . 2001 . 10945465 . 10.1006/geno.2000.6226 .

External links

• Web site: GPRC5 Receptors: RAIG₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-04 . 2014-08-08 . https://web.archive.org/web/20140808051224/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2960 . dead .

Notes and References

1. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . Nov 1999 . 10493829 . 10.1006/geno.1999.5927 .
2. Bräuner-Osborne H, Krogsgaard-Larsen P . Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain . Genomics . 65 . 2 . 121–8 . Jul 2000 . 10783259 . 10.1006/geno.2000.6164 .
3. Web site: Entrez Gene: GPRC5B G protein-coupled receptor, family C, group 5, member B.