GPR63 explained
Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.[1]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][2]
Further reading
- Kawasawa Y, Kume K, Nakade S, etal . Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. . Biochem. Biophys. Res. Commun. . 276 . 3 . 952–6 . 2000 . 11027574 . 10.1006/bbrc.2000.3569 .
- Kawasawa Y, Kume K, Izumi T, Shimizu T . Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. . Biochem. Biophys. Res. Commun. . 276 . 3 . 957–64 . 2000 . 11027575 . 10.1006/bbrc.2000.3570 .
- Lee DK, George SR, Cheng R, etal . Identification of four novel human G protein-coupled receptors expressed in the brain. . Brain Res. Mol. Brain Res. . 86 . 1–2 . 13–22 . 2001 . 11165367 . 10.1016/S0169-328X(00)00242-4 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Niedernberg A, Tunaru S, Blaukat A, etal . Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63 . Cell. Signal. . 15 . 4 . 435–46 . 2004 . 12618218 . 10.1016/S0898-6568(02)00119-5 . 10.1.1.486.4056 .
- Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
Notes and References
- Web site: Entrez Gene: GPR63 G protein-coupled receptor 63.
- Web site: Entrez Gene: GPR63 G protein-coupled receptor 63.
