GPR6 explained

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.^{[1] [2]}

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.^[3]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.^[4]

Ligand

Inverse Agonist

• Cannabidiol^[5]

Evolution

Source:^[6]

• GPR3
  • GPR12 S1PR5
• S1PR1
• CNR1
• S1PR2
• LPAR2
• CNR2
• MC1R
• S1PR3
• S1PR4
• GPR119
• MC3R
• MC4R
• MC5R
• LPAR1
• LPAR3
• MC2R

See also

• Lysophospholipid receptor

Further reading

• Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, Marchese A, Tsui LC, Shi X, George SR . 6 . Isolation of three novel human genes encoding G protein-coupled receptors . DNA and Cell Biology . 14 . 1 . 25–35 . January 1995 . 7832990 . 10.1089/dna.1995.14.25 .
• Song ZH, Modi W, Bonner TI . Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors . Genomics . 28 . 2 . 347–349 . July 1995 . 8530049 . 10.1006/geno.1995.1154 .
• Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E . Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells . Cellular Physiology and Biochemistry . 13 . 2 . 75–84 . 2003 . 12649592 . 10.1159/000070251 . 45156405 .

External links

• Web site: GPR6 . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2009-04-24 . 2012-09-02 . https://web.archive.org/web/20120902024823/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3091 . dead .

Notes and References

1. Web site: Entrez Gene: GPR6 G protein-coupled receptor 6.
2. Song ZH, Modi W, Bonner TI . Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors . Genomics . 28 . 2 . 347–349 . July 1995 . 8530049 . 10.1006/geno.1995.1154 .
3. Uhlenbrock K, Gassenhuber H, Kostenis E . Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors . Cellular Signalling . 14 . 11 . 941–953 . November 2002 . 12220620 . 10.1016/S0898-6568(02)00041-4 .
4. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y . Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth . The Journal of Biological Chemistry . 282 . 14 . 10506–10515 . April 2007 . 17284443 . 10.1074/jbc.M700911200 . free .
5. Laun AS, Shrader SH, Brown KJ, Song ZH . GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol . Acta Pharmacologica Sinica . 40 . 3 . 300–308 . March 2019 . 29941868 . 6460361 . 10.1038/s41401-018-0031-9 .
6. Web site: GeneCards®: The Human Gene Database .