GPR34 explained

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.^{[1] [2] [3]}

Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]

Further reading

• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . Generation and analysis of 280,000 human expressed sequence tags . Genome Research . 6 . 9 . 807–28 . September 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
• Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM . Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1 . Human Genetics . 107 . 1 . 89–91 . July 2000 . 10982042 . 10.1007/s004390050017 .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Engemaier E, Römpler H, Schöneberg T, Schulz A . Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34 . Genomics . 87 . 2 . 254–64 . February 2006 . 16338117 . 10.1016/j.ygeno.2005.10.001 .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mammalian Genome . 16 . 12 . 942–54 . December 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A . Altered immune response in mice deficient for the G protein-coupled receptor GPR34 . The Journal of Biological Chemistry . 286 . 3 . 2101–10 . January 2011 . 21097509 . 3023507 . 10.1074/jbc.M110.196659 . free .
• Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T . The ligand specificity of the G-protein-coupled receptor GPR34 . The Biochemical Journal . 443 . 3 . 841–50 . May 2012 . 22348703 . 10.1042/BJ20112090 .

Notes and References

1. Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T . A novel subgroup of class I G-protein-coupled receptors . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1446 . 1–2 . 57–70 . July 1999 . 10395919 . 10.1016/s0167-4781(99)00081-0 .
2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF . Discovery of three novel orphan G-protein-coupled receptors . Genomics . 56 . 1 . 12–21 . February 1999 . 10036181 . 10.1006/geno.1998.5655 .
3. Web site: Entrez Gene: GPR34 G protein-coupled receptor 34.