GPR182 explained

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.^[1]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.^[2] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).^[3]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.^[4]

Further reading

• Lah JJ, Frishman WH . Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential . Heart Disease (Hagerstown, Md.) . 2 . 3 . 259–65 . 2002 . 11728267 .
• Mukoyama M . Role of adrenomedullin and its receptor system in renal pathophysiology . Peptides . 22 . 11 . 1925–1931 . 2002 . 11754983 . 10.1016/S0196-9781(01)00525-3 . vanc. Sugawara A . Nagae T . 3 . Mori . K . Murabe . H . Itoh . H . Tanaka . I . Nakao . K . 3137509 .
• Fowler DE, Wang P . The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review) . Int. J. Mol. Med. . 9 . 5 . 443–9 . 2002 . 11956648 . 10.3892/ijmm.9.5.443.
• Kato J, Kitamura K, Kangawa K, Eto T . Receptors for adrenomedullin in human vascular endothelial cells . Eur. J. Pharmacol. . 289 . 2 . 383–385 . 1995 . 7621913 . 10.1016/0922-4106(95)90117-5 .
• Martínez A, Miller MJ, Catt KJ, Cuttitta F . Adrenomedullin receptor expression in human lung and in pulmonary tumors . J. Histochem. Cytochem. . 45 . 2 . 159–64 . 1997 . 9016306 . 10.1177/002215549704500202 . free .
• Hänze J, Dittrich K, Dötsch J, Rascher W . Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system . Biochem. Biophys. Res. Commun. . 240 . 1 . 183–188 . 1997 . 9367907 . 10.1006/bbrc.1997.7631 .
• Martínez A . Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument . Endocrinology . 138 . 12 . 5597–5604 . 1997 . 9389548 . 10.1210/endo.138.12.5622 . vanc. Elsasser TH . Muro-Cacho C . 3 . Moody . TW . Miller . MJ . Macri . CJ . Cuttitta . F . free .
• Kennedy SP . Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response . Biochem. Biophys. Res. Commun. . 244 . 3 . 832–837 . 1998 . 9535752 . 10.1006/bbrc.1998.8349 . vanc. Sun D . Oleynek JJ . 3 . Hoth . CF . Kong . J . Hill . RJ .
• Jiménez N . Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate . J. Histochem. Cytochem. . 47 . 9 . 1167–78 . 1999 . 10449538 . 10.1177/002215549904700909 . vanc. Calvo A . Martínez A . 3 . Rosell . D . Cuttitta . F . Montuenga . LM . free . 10171/20168 . free .
• Kuwasako K . The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors . J. Biol. Chem. . 276 . 52 . 49459–49465 . 2002 . 11591721 . 10.1074/jbc.M108369200 . vanc. Kitamura K . Ito K . 3 . Uemura . T . Yanagita . Y . Kato . J . Sakata . T . Eto . T . free .
• Forneris M . Expression and function of adrenomedullin and its receptors in Conn's adenoma cells . Int. J. Mol. Med. . 8 . 6 . 675–9 . 2002 . 11712085 . 10.3892/ijmm.8.6.675. vanc. Gottardo L . Albertin G . 3 . Malendowicz . LK . Nussdorfer . GG .
• Hänze J . Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia . Biochem. Biophys. Res. Commun. . 291 . 5 . 1160–1165 . 2002 . 11883938 . 10.1006/bbrc.2002.6595 . vanc. Groneberg DA . Rose F . 3 . Hanisch . A . Dötsch . J . Peiser . C . Seeger . W . Rascher . W . Fischer . A .
• Dumont CE . Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats . Brain Res. . 955 . 1–2 . 64–71 . 2003 . 12419522 . 10.1016/S0006-8993(02)03365-6 . vanc. Muff R . Flühmann B . 3 . Fischer . JA . Born . W . 33819362 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Chosa E . Expression of adrenomedullin and its receptor by chondrocyte phenotype cells . Biochem. Biophys. Res. Commun. . 303 . 1 . 379–386 . 2003 . 12646214 . 10.1016/S0006-291X(03)00347-4 . vanc. Hamada H . Kitamura K . 3 . Kuwasako . Kenji . Yanagita . Toshihiko . Eto . Tanenao . Tajima . Naoya .
• Xu P . [Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease] . Zhonghua Jie He He Hu Xi Za Zhi . 26 . 12 . 765–8 . 2004 . 14720432 . vanc. Dai AG . Zhou HD . 3 . Shen . HW . Liu . LH . Song . WD .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

External links

• Web site: GPR182 . 2007-12-04 . IUPHAR GPCR Database . International Union of Pharmacology (IUPHAR) . 2008-07-03.

Notes and References

1. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA . The G protein-coupled receptor repertoires of human and mouse . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4903–4908 . April 2003 . 12679517 . 153653 . 10.1073/pnas.0230374100 . 2003PNAS..100.4903V . free .
2. Hänze J, Dittrich K, Dötsch J, Rascher W . Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system . Biochem. Biophys. Res. Commun. . 240 . 1 . 183–188 . November 1997 . 9367907 . 10.1006/bbrc.1997.7631 .
3. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ . Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response . Biochem. Biophys. Res. Commun. . 244 . 3 . 832–837 . March 1998 . 9535752 . 10.1006/bbrc.1998.8349 .
4. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM . RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor . Nature . 393 . 6683 . 333–339 . May 1998 . 9620797 . 10.1038/30666 . 1998Natur.393..333M . 4364526 .