GPR144 explained

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene.^{[1] [2]} This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^{[3] [4]}

Further reading

• Vassilatis DK, Hohmann JG, Zeng H . The G protein-coupled receptor repertoires of human and mouse. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4903–8 . 2003 . 12679517 . 10.1073/pnas.0230374100 . 153653 . 2003PNAS..100.4903V . etal. free .
• Humphray SJ, Oliver K, Hunt AR . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H . etal.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . etal.

Notes and References

1. Web site: Entrez Gene: GPR144 G protein-coupled receptor 144.
2. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Lett . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
3. Book: Stacey M, Yona S . AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
4. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . EMBO J. . 31 . 6 . 1364–78 . March 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .