GPR133 explained

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.^{[1] [2]}

This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^{[3] [4]}

Further reading

• Vanti WB, Nguyen T, Cheng R . Novel human G-protein-coupled receptors. . Biochem. Biophys. Res. Commun. . 305 . 1 . 67–71 . 2003 . 12732197 . 10.1016/S0006-291X(03)00709-5 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Web site: Entrez Gene: GPR133 G protein-coupled receptor 133.
2. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB . Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions . FEBS Lett . 531 . 3 . 407–14 . Nov 2002 . 12435584 . 10.1016/S0014-5793(02)03574-3 . 7449692 . free .
3. Book: Stacey M, Yona S . AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
4. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT . A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis . EMBO J. . 31 . 6 . 1364–78 . March 2012 . 22333914 . 3321182 . 10.1038/emboj.2012.26 .